Reactome | Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways Show undefined attributes

author

[Person:192204] Pikuleva, IA
[Person:193539] Babiker, A
[Person:193061] Waterman, MR
[Person:192041] Bjorkhem, I

created [InstanceEdit:193476] D'Eustachio, P, 2007年02月19日 17:36:33

dbId 193375

displayName Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

journal J Biol Chem

pages 18153-60

pubMedIdentifier 9660774

schemaClass LiteratureReference

title Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways

url http://www.ncbi.nlm.nih.gov/pubmed/9660774

volume 273

year 1998

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(literatureReference)

[Pathway:R-HSA-5578996] Defective CYP27A1 causes CTX
[Reaction:R-HSA-192054] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)
[Reaction:R-HSA-192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
[Reaction:R-HSA-193713] 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)
[Reaction:R-HSA-193780] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
[Reaction:R-HSA-193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol
[Reaction:R-HSA-193460] 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)
[Reaction:R-HSA-193497] 5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al
[Reaction:R-HSA-193393] 5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol
[Reaction:R-HSA-193737] 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)
[Reaction:R-HSA-193719] 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al
[FailedReaction:R-HSA-5602170] CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol
[Reaction:R-HSA-191999] CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol
[FailedReaction:R-HSA-9035960] Defective CYP27A1 does not 27-hydroxylate 5?-CHOL3?,7?,24(s)-triol
[Reaction:R-HSA-193792] CYP27A1 27-hydroxylates 5?-CHOL3?,7?,24(s)-triol

(author)

[Person:192204] Pikuleva, IA
[Person:192041] Bjorkhem, I
[Person:193061] Waterman, MR
[Person:193539] Babiker, A

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