Reactome Pathway Database

Schema > Reaction > Entries

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) Show undefined attributes

authored

[InstanceEdit:191331] Jassal, Bijay, 2007年01月19日

catalystActivity

[CatalystActivity:192037] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:191989] Jassal, Bijay, 2007年01月26日

dbId 192054

displayName 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)

edited

[InstanceEdit:193475] D'Eustachio, P, 2007年02月17日 19:40:28

eventOf

[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-191971] THCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

name

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA) + NADP+ + H2O

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-192042] 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al - Homo sapiens

releaseDate 2007年05月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:197117] D'Eustachio, P, 2007年04月30日 14:43:26

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-192054

summation

[Summation:192131] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al, NADP...

Referrals

(hasEvent)

[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

(precedingEvent)

[BlackBoxEvent:R-HSA-191971] THCA is translocated from the mitochondrial matrix to the cytosol

© 2025 Reactome

Cite Us!