Reactome Pathway Database

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3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) Show undefined attributes

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authored

[InstanceEdit:193783] D'Eustachio, P, 2007年02月23日 20:35:09

catalystActivity

[CatalystActivity:192037] steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:193768] D'Eustachio, P, 2007年02月23日 20:48:08

dbId 193713

displayName 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)

edited

[InstanceEdit:193783] D'Eustachio, P, 2007年02月23日 20:35:09

eventOf

[Pathway:R-HSA-193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-193722] TetraHCA is translocated from the mitochondrial matrix to the cytosol - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

name

3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) + NADP+ + H2O

orthologousEvent