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Reactome Pathway Database
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What is Reactome ?
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Funding
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Digital Preservation
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Docs
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Details Panel
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Diseases
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Schema
>
DatabaseIdentifier
>
Entries
Mondo:0020325
Show undefined attributes
databaseName
Mondo
dbId
11944985
displayName
Mondo:0020325
identifier
0020325
referenceDatabase
[ReferenceDatabase:11944889] Mondo
schemaClass
DatabaseIdentifier
url
https://monarchinitiative.org/MONDO:0020325
Referrals
(crossReference)
[EntityWithAccessionedSequence:R-HSA-9715266] ALK Y1239H [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715263] ALK H694R [plasma membrane]
[Complex:R-HSA-9715321] ALK V597A dimer [plasma membrane]
[Complex:R-HSA-9715322] ALK H694R dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715265] ALK V597A [plasma membrane]
[Complex:R-HSA-9715314] ALK S413N dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715287] p-7Y ALK S413N [plasma membrane]
[Complex:R-HSA-9715317] p-7Y ALK S413N dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9702038] TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol]
[Complex:R-HSA-9702034] TFG(1-240)-ALK(1058-1620) fusion dimer [cytosol]
[Complex:R-HSA-9850901] NPM1-ALK;NPM1:FOXM1 [nucleoplasm]
[Complex:R-HSA-9715325] ALK E1384K dimer [plasma membrane]
[Complex:R-HSA-9710898] ATIC(1-229)-ALK(1058-1620) fusion dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9715286] p-7Y ALK G881D [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715284] RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9715280] MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
[Complex:R-HSA-9850898] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer:PI3K [cytosol]
[EntityWithAccessionedSequence:R-HSA-9710829] ATIC(1-229)-ALK(1058-1620) fusion [cytosol]
[Complex:R-HSA-9715319] p-7Y ALK H694R dimer [plasma membrane]
[Complex:R-HSA-9715313] ALK G881D dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715293] p-7Y ALK H694R [plasma membrane]
[Complex:R-HSA-9850945] pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9715262] ALK E1384K [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9710832] ATIC(1-230)-ALK(1059-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9715285] p-7Y ALK E1384K [plasma membrane]
[Complex:R-HSA-9702041] TFG(1-240)-p-7Y ALK(1058-1620) fusion dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9710837] TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9711966] MSN(2-448)-ALK(1064-1620) fusion [cytosol]
[Complex:R-HSA-9710872] ATIC(1-229)-p-7Y ALK(1058-1620) fusion dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9699887] TFG(1-193)-ALK(1058-1620) fusion [cytosol]
[Complex:R-HSA-9715327] p-7Y ALK G881D dimer [plasma membrane]
[Complex:R-HSA-9702032] TFG(1-193)-p-7Y ALK(1058-1620) dimer [cytosol]
[Complex:R-HSA-9700521] ALK L1196Q dimer [plasma membrane]
[Complex:R-HSA-9702022] TFG(1-138)-p-7Y ALK(1058-1620) fusion dimer [cytosol]
[Complex:R-HSA-9702017] TFG(1-138)-ALK(1058-1620) fusion dimer [cytosol]
[Complex:R-HSA-9700531] p-7Y ALK L1196Q dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9710839] EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9715267] ALK S413N [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9699806] TFG(1-240)-ALK(1058-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9715295] p-7Y ALK V597A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715260] ALK G881D [plasma membrane]
[Complex:R-HSA-9710882] TPM3(2-258)-p-7Y ALK(1059-1620) fusion dimer [cytosol]
[Complex:R-HSA-9702025] TFG(1-193)-ALK(1058-1620) dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9710850] EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]
[Complex:R-HSA-9850905] crizotinib:NPM1-ALK fusion dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9710833] ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9700476] p-7Y ALK L1196Q [plasma membrane]
[Complex:R-HSA-9712020] MSN(2-448)-p-7Y ALK(1064-1620) fusion dimer [cytosol]
[BlackBoxEvent:R-HSA-9851098] NPM1-ALK- and JUN-dependent CDKN1A gene repression
[BlackBoxEvent:R-HSA-9851088] JUNB- and NPM1-ALK-mediated GZMB gene expression
[Reaction:R-HSA-9851118] pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK
[BlackBoxEvent:R-HSA-9851068] Crizotinib-driven IL10RA gene expression in NPM1-ALK
[Reaction:R-HSA-9851122] p-Y705,S727 STAT3 dimer binds NOTCH gene
[BlackBoxEvent:R-HSA-9851104] NPM1-ALK- and STAT3-dependent ICOS gene expression
[BlackBoxEvent:R-HSA-9851142] TYK2-dependent STAT1 and STAT3 phosphorylation
[BlackBoxEvent:R-HSA-9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants
[BlackBoxEvent:R-HSA-9725338] NPM1-ALK-dependent BCL2A1 gene expression
[BlackBoxEvent:R-HSA-9851096] NPM1-ALK- and JNK-dependent JUN phosphorylation
[Reaction:R-HSA-9851084] JUNB dimer binds GZMB promoter
[Reaction:R-HSA-9851076] p-T,Y MAPK8,9 bind TP53
[BlackBoxEvent:R-HSA-9851131] NPM1-ALK-stimulated PRF1 gene expression
[BlackBoxEvent:R-HSA-9851109] NPM1-ALK- and STAT3-dependent TWIST gene expression
[BlackBoxEvent:R-HSA-9851078] NPM1-ALK-dependent MAPK8,9 phosphorylation
[BlackBoxEvent:R-HSA-9851133] STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing
[BlackBoxEvent:R-HSA-9851117] NPM1-ALK- and p-STAT3-dependent IRF4 gene expression
[BlackBoxEvent:R-HSA-9851123] NPM1-ALK- and p-STAT3-dependent NOTCH gene expression
[Reaction:R-HSA-9851090] NPM1-ALK binds NPM1 and FOXM1
[BlackBoxEvent:R-HSA-9851077] JNK-dependent inhibition of TP53 ubiquitination
[Reaction:R-HSA-9851106] p-Y705, S727 STAT3 dimer binds ICOS promoter
[BlackBoxEvent:R-HSA-9851102] NPM1-ALK- and PI3K-dependent MDM2 phosphorylation
[BlackBoxEvent:R-HSA-9851112] NPM1-ALK- and TYK2-dependent MCL1 gene expression
[Reaction:R-HSA-9851114] NPM1-ALK-dependent TYK2 phosphorylation
[BlackBoxEvent:R-HSA-9851092] NPM1-ALK and FOXM1-dependent CCNB1 gene expression
[BlackBoxEvent:R-HSA-9851079] p-T,Y MAPK8,9 translocate to the nucleus
[BlackBoxEvent:R-HSA-9851127] NPM1-ALK-dependent repression of pRB phosphorylation
[BlackBoxEvent:R-HSA-9725357] NPM1-ALK-dependent CEBPB gene expression
[EntityWithAccessionedSequence:R-HSA-9711971] MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
[Complex:R-HSA-9710873] ATIC(1-230)-p-7Y ALK(1059-1620) fusion dimer [cytosol]
[Complex:R-HSA-9715320] p-7Y ALK E1384K dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9702029] TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol]
[Complex:R-HSA-9712017] MSN(2-448)-ALK(1064-1620) fusion dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9710848] TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol]
[Complex:R-HSA-9710881] EEF1G(1-343)-6Y ALK(1106-1620) fusion dimer [cytosol]
[Complex:R-HSA-9710897] ATIC(1-230)-ALK(1059-1620) fusion dimer [cytosol]
[Complex:R-HSA-9715326] p-7Y ALK Y1239H dimer [plasma membrane]
[Complex:R-HSA-9715318] ALK Y1239H dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715290] p-7Y ALK Y1239H [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9715291] RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
[Complex:R-HSA-9710891] EEF1G(1-343)-ALK(1106-1620) fusion dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9710847] ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9699874] TFG(1-138)-ALK(1058-1620) fusion [cytosol]
[Complex:R-HSA-9710892] TPM3(2-258)-ALK(1059-1620) fusion dimer [cytosol]
[EntityWithAccessionedSequence:R-HSA-9715279] MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
[EntityWithAccessionedSequence:R-HSA-9702019] TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol]
[Complex:R-HSA-9715330] p-7Y ALK V597A dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9700472] ALK L1196Q [plasma membrane]
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