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pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK Show undefined attributes

authored

[InstanceEdit:9851210] Rothfels, Karen, 2023年10月14日

category binding

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:9851119] Rothfels, Karen, 2023年10月12日

crossReference

dbId 9851118

disease

displayName pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK

edited

[InstanceEdit:9851215] Rothfels, Karen, 2023年10月14日

eventOf

[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-9851117] NPM1-ALK- and p-STAT3-dependent IRF4 gene expression - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9852942] Rothfels, Karen, 2023年11月08日

name

pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK

output

[Complex:R-HSA-9850945] pY705, S727-STAT3 dimer:IRF4 gene [nucleoplasm]

precedingEvent

[BlackBoxEvent:R-HSA-9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants - Homo sapiens

releaseDate 2023年12月06日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9851118

summation

[Summation:9850807] STAT3 binds to cognate binding sites in the promoter of IRF4...

Referrals

(precedingEvent)

[BlackBoxEvent:R-HSA-9851117] NPM1-ALK- and p-STAT3-dependent IRF4 gene expression

(hasEvent)

[Pathway:R-HSA-9725371] Nuclear events stimulated by ALK signaling in cancer

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