Reactome Pathway Database

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Mondo:0015280 Show undefined attributes

databaseName Mondo

dbId 11944926

displayName Mondo:0015280

identifier 0015280

referenceDatabase [ReferenceDatabase:11944889] Mondo

schemaClass DatabaseIdentifier

url https://monarchinitiative.org/MONDO:0015280

Referrals

(crossReference)

[EntityWithAccessionedSequence:R-HSA-9651177] KRAS K147N [plasma membrane]
[Complex:R-HSA-9652131] MAP2K2 F57C dimer [cytosol]
[CandidateSet:R-HSA-9649710] RAS GEF mutants [plasma membrane]
[Reaction:R-HSA-6802938] Inhibitors bind and inhibit highly active BRAF mutants
[FailedReaction:R-HSA-9651280] RAS GAP mutants aren't stimulated by GAPs
[Reaction:R-HSA-6803227] Dissociation of high activity BRAF complexes
[Pathway:R-HSA-9652169] Signaling by MAP2K mutants
[Reaction:R-HSA-6802912] High kinase activity BRAF mutants bind MAP2Ks and MAPKs
[Reaction:R-HSA-9652165] MAP2K mutants constitutively phosphorylate MAPKs
[EntityWithAccessionedSequence:R-HSA-9648634] p-BRAF G469E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9651157] BRAF Q257R [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651194] p-BRAF T244P [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-6802316] BRAF F595L [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651138] BRAF G596V [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651276] KRAS P34R [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9652034] MAP2K1 F53S [cytosol]
[Complex:R-HSA-9651282] RAS GAP mutants:GTP [plasma membrane]
[CandidateSet:R-HSA-9652114] MAP2K1 and MAP2K2 mutants [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651152] BRAF N581D [cytosol]
[EntityWithAccessionedSequence:R-HSA-9648618] BRAF G469E [cytosol]
[EntityWithAccessionedSequence:R-HSA-8936641] p-BRAF F595L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9651123] BRAF A246P [cytosol]
[EntityWithAccessionedSequence:R-HSA-9652101] MAP2K1 Y130C [cytosol]
[CandidateSet:R-HSA-9651281] RAS GAP mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9651188] p-BRAF A246P [plasma membrane]
[Complex:R-HSA-6802666] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol]
[Complex:R-HSA-9652104] MAP2K2 P128Q dimer [cytosol]
[CandidateSet:R-HSA-8936658] phosphorylated moderate kinase activity BRAF mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9651125] BRAF D638E [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651147] BRAF L485F [cytosol]
[Complex:R-HSA-9652126] MAP2K1 D67Y dimer [cytosol]
[Complex:R-HSA-6802664] high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol]
[CandidateSet:R-HSA-6802641] moderate kinase activity BRAF mutants [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651132] BRAF E501G [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651372] KRAS F156L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9651169] KRAS K147E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9651191] p-BRAF N581D [plasma membrane]
[DefinedSet:R-HSA-6802579] high kinase activity BRAF mutants [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651180] KRAS K147T [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9651142] BRAF K499E [cytosol]
[EntityWithAccessionedSequence:R-HSA-9652089] MAP2K2 Y134C [cytosol]
[EntityWithAccessionedSequence:R-HSA-9652016] MAP2K1 D67N [cytosol]
[Complex:R-HSA-6802662] high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol]
[DefinedSet:R-HSA-6802631] genetically or chemically inactive BRAF [cytosol]
[EntityWithAccessionedSequence:R-HSA-9652019] MAP2K1 D67Y [cytosol]
[EntityWithAccessionedSequence:R-HSA-9652082] MAP2K2 P128Q [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651165] BRAF T244P [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651161] BRAF S467A [cytosol]
[EntityWithAccessionedSequence:R-HSA-9652073] MAP2K2 F57C [cytosol]
[EntityWithAccessionedSequence:R-HSA-9651134] BRAF G534R [cytosol]
[Complex:R-HSA-6802578] BRAF inhibitors:high kinase activity BRAF mutants [cytosol]

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