Modulation of the Kv3.1b Potassium Channel Isoform Adjusts the Fidelity of the Firing Pattern of Auditory Neurons

@article{Macica2003ModulationOT,
 title={Modulation of the Kv3.1b Potassium Channel Isoform Adjusts the Fidelity of the Firing Pattern of Auditory Neurons},
 author={Carolyn M. Macica and Christian A. A. von Hehn and Lu-Yang Wang and Chi Shun Ho and Shigeru Yokoyama and Rolf H. Joho and Leonard K. Kaczmarek},
 journal={The Journal of Neuroscience},
 year={2003},
 volume={23},
 pages={1133 - 1141},
 url={https://api.semanticscholar.org/CorpusID:17564494}
}
Modulation of Kv3.1 by phosphorylation allows auditory neurons to tune their responses to different patterns of sensory stimulation, and suggests that modulation of K v3.2 current is sufficient to increase the accuracy of response at intermediate frequencies while impairing responses at high frequencies.

142 Citations

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Analysis of patch‐clamp, in situ hybridization and computer simulation techniques concludes that in mouse MNTB neurones the Kv3.1 channel contributes to the ability of these cells to lock their firing to high‐frequency inputs.

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