Skip to search form Skip to main content Skip to account menu
Semantic ScholarSemantic Scholar's Logo

Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP
The cloning of a gene encoding a K+ channel, Slick, is reported, and it is demonstrated that functionally it is a hybrid between two classes of K+ channels, Na+-activated (KNa) and ATP-sensitive (KATP) K- channels.

Localization of the Slack potassium channel in the rat central nervous system
The subcellular and regional distribution of Slack differs from that previously reported for the Slo channel subunit and suggests that Slack may also have an autonomous role in regulating the firing properties of neurons.

Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons
Using computational modeling, it is shown that high amounts of Kv3.1 current decrease the timing accuracy of action potentials but enable neurons to follow high-frequency stimuli, indicating that the intrinsic electrical properties of auditory neurons are rapidly modified to adjust to the ambient acoustic environment.

The N-Terminal Domain of Slack Determines the Formation and Trafficking of Slick/Slack Heteromeric Sodium-Activated Potassium Channels
This work has found that Slick and Slack subunits coassemble to form heteromeric channels that differ from the homomers in their unitary conductance, kinetic behavior, subcellular localization, and response to activation of protein kinase C.

Amino‐termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation
It is determined that alternative RNA splicing gives rise to at least five different transcripts for Slack, which produce Slack channels that differ in their predicted cytoplasmic amino‐termini and in their kinetic properties.

PKA-Induced Internalization of Slack KNa Channels Produces Dorsal Root Ganglion Neuron Hyperexcitability
The data suggest that the change in nociceptive firing occurring during inflammation is the result of PKA-induced Slack channel trafficking, and it is found that knocking down the Slack subunit by RNA interference causes a loss of firing accommodation analogous to that observed during PKA activation.

Sodium‐dependent potassium channels of a Slack‐like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons
The results strongly indicate that a KNa potassium current contributes importantly to the sAHP and thereby to neuronal frequency regulation during high level burst activity as during locomotion.

Localization of the Na+‐activated K+ channel Slick in the rat central nervous system
The existence of two genes that encode KNa, that are widely expressed in the nervous system, with both overlapping and nonoverlapping distributions, provides the basis for the reported heterogeneity in the properties of KNa from various neurons.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)
[フレーム]

AltStyle によって変換されたページ (->オリジナル) /