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Schema
>
Reaction
>
Entries
Viral Spike Binds to ACE2 on Uninfected Cell
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authored
[InstanceEdit:9815534] Stephan, Ralf, 2022年08月18日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9733469] Stephan, Ralf, 2021年06月04日
crossReference
[DatabaseIdentifier:11944893] Mondo:0100096
dbId
9733495
disease
[Disease:9683912] COVID-19
displayName
Viral Spike Binds to ACE2 on Uninfected Cell
edited
[InstanceEdit:9815534] Stephan, Ralf, 2022年08月18日
entityOnOtherCell
[EntityWithAccessionedSequence:R-HSA-9683480] glycosylated-ACE2 [plasma membrane] - Homo sapiens
eventOf
[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion - Homo sapiens
followingEvent
[Reaction:R-HSA-9769949] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9683480] glycosylated-ACE2 [plasma membrane]
[Complex:R-COV-9733504] Spike trimer [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9683520] Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target
[LiteratureReference:9733499] Syncytia formation by SARS-CoV-2-infected cells
[LiteratureReference:9769807] Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
[LiteratureReference:9733465] SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Viral Spike Binds to ACE2 on Uninfected Cell
negativePrecedingEvent
[NegativePrecedingEvent:9763986] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
output
[Complex:R-HSA-9770060] Spike trimer:ACE2 [plasma membrane]
precedingEvent
[BlackBoxEvent:R-HSA-9769812] Spike Trimer Translocates to the Plasma Membrane - Homo sapiens
relatedSpecies
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2022年09月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9773891] Gillespie, Marc E, 2022年05月10日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9733495
summation
[Summation:9770069] Excess SARS-CoV-2 spike protein accumulates in the plasma me...
Referrals
(precedingEvent)
[Reaction:R-HSA-9769949] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
(hasEvent)
[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion
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