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Schema
>
Pathway
>
Entries
Induction of Cell-Cell Fusion
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authored
[InstanceEdit:9796131] Stephan, Ralf, 2022年08月05日
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9733469] Stephan, Ralf, 2021年06月04日
crossReference
[DatabaseIdentifier:11944893] Mondo:0100096
dbId
9733458
disease
[Disease:9683912] COVID-19
displayName
Induction of Cell-Cell Fusion
edited
[InstanceEdit:9796426] Stephan, Ralf, 2022年08月09日
eventOf
[Pathway:R-HSA-9772573] Late SARS-CoV-2 Infection Events - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:262470] symbiont-mediated induction of syncytium formation
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-9769812] Spike Trimer Translocates to the Plasma Membrane - Homo sapiens
[Reaction:R-HSA-9733495] Viral Spike Binds to ACE2 on Uninfected Cell - Homo sapiens
[Reaction:R-HSA-9769949] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage - Homo sapiens
[BlackBoxEvent:R-HSA-9770063] S1,S2 Dissociate from S1:ACE2:S2 - Homo sapiens
[Reaction:R-HSA-9770187] S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9769784] The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation
[LiteratureReference:9733465] SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
[LiteratureReference:9733499] Syncytia formation by SARS-CoV-2-infected cells
[LiteratureReference:9698993] A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
[LiteratureReference:9698397] Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
[LiteratureReference:9733490] Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
[LiteratureReference:9769803] SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination
[LiteratureReference:9770213] Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern
[LiteratureReference:9770308] SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation
[LiteratureReference:9770326] D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage
maxDepth
2
modified
[InstanceEdit:9953252] Stephan, Ralf, 2025年05月30日
name
Induction of Cell-Cell Fusion
relatedSpecies
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2022年09月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9773891] Gillespie, Marc E, 2022年05月10日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9733458
summation
[Summation:9733489] Many enveloped viruses induce multinucleated cells (syncytia...
Referrals
(hasEvent)
[Pathway:R-HSA-9772573] Late SARS-CoV-2 Infection Events
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