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Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
catalystActivity
[CatalystActivity:5655287] guanyl-nucleotide exchange factor activity of FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655347
deleted
[Deleted:5655673] Deletion of instance: 1982085
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:5655317] gain_of_function of FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
eventOf
[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:2011995] FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
[LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells
[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
[LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations
[LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
[LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
normalReaction
[Reaction:R-HSA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655347
summation
[Summation:1982087] Activation of Erk1/2 downstream of FGFR mutants suggests tha...
updateTrackers
[UpdateTracker:9775325] Update Tracker - [Reaction:5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - v79:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775325] Update Tracker - [Reaction:5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - v79:[modifyText]
(replacementInstances)
[Deleted:5655673] Deletion of instance: 1982085
(hasEvent)
[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease
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