Reactome | Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation Show undefined attributes

author

[Person:2029741] Byron, SA
[Person:1614693] Gartside, MG
[Person:2029793] Wellens, CL
[Person:1614704] Mallon, MA
[Person:2032847] Keenan, JB
[Person:1614715] Powell, MA
[Person:1614694] Goodfellow, PJ
[Person:1614151] Pollock, PM

created [InstanceEdit:2032930] Rothfels, K, 2012年01月08日

dbId 2032931

displayName Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation

journal Cancer Res

pages 6902-7

pubMedIdentifier 18757403

schemaClass LiteratureReference

title Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation

url http://www.ncbi.nlm.nih.gov/pubmed/18757403

volume 68

year 2008

Referrals

(literatureReference)

[Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5655252] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
[Reaction:R-HSA-5655241] Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5655320] Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655323] Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5655245] Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
[Pathway:R-HSA-1839126] FGFR2 mutant receptor activation
[Pathway:R-HSA-2033519] Activated point mutants of FGFR2
[Reaction:R-HSA-2033488] Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding
[Reaction:R-HSA-2033490] Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity
[Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands
[Reaction:R-HSA-2033479] Dimerization of FGFR2 point mutants with enhanced kinase activity
[EntityWithAccessionedSequence:R-HSA-1637910] FGFR2 N549K [plasma membrane]
[Reaction:R-HSA-2033486] Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding
[Reaction:R-HSA-2033472] FGFR2c mutants bind an expanded range of ligands
[Reaction:R-HSA-2029983] Dimerization of FGFR2 ligand-independent mutants
[Reaction:R-HSA-5655289] Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5655277] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[Reaction:R-HSA-5655315] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
[Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
[Reaction:R-HSA-5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
[ChemicalDrug:R-ALL-2038919] PD173074 [cytosol]

(author)

[Person:1614151] Pollock, PM
[Person:2029793] Wellens, CL
[Person:1614694] Goodfellow, PJ
[Person:1614693] Gartside, MG
[Person:1614704] Mallon, MA
[Person:1614715] Powell, MA
[Person:2029741] Byron, SA
[Person:2032847] Keenan, JB

Reactome Pathway Database

Reactome Pathway Database

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation Show undefined attributes

Referrals

Cite Us!

Download As: