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Entries
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
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authored
[InstanceEdit:2105031] Rothfels, K, 2012年02月09日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655240
deleted
[Deleted:5655675] Deletion of instance: 1986643
disease
[Disease:2032940] bone development disease
[Disease:1500689] cancer
displayName
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
edited
[InstanceEdit:2252592] Rothfels, K, 2012年05月16日
entityFunctionalStatus
[EntityFunctionalStatus:9632021] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
eventOf
[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
followingEvent
[Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
input
[Complex:R-HSA-5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[Complex:R-HSA-179864] GRB2:GAB1:PIK3R1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
[LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
[LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
[LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
normalReaction
[Reaction:R-HSA-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
output
[Complex:R-HSA-5655218] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2 - Homo sapiens
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655240
summation
[Summation:1986644] FGFR1-amplified cells derived from lung cancer patients show...
Referrals
(replacementInstances)
[Deleted:5655675] Deletion of instance: 1986643
(hasEvent)
[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease
(precedingEvent)
[Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
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