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Schema
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Pathway
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Entries
Signaling by FGFR1 in disease
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authored
[InstanceEdit:5649621] Rothfels, Karen, 2014年11月20日
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:12757882] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:11944971] Mondo:0005497
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
dbId
5655302
deleted
[Deleted:6789863] Deletion of instance: 5655311
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Signaling by FGFR1 in disease
edited
[InstanceEdit:5655401] Rothfels, Karen, 2014年12月05日
eventOf
[Pathway:R-HSA-1226099] Signaling by FGFR in disease - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-1839124] FGFR1 mutant receptor activation - Homo sapiens
[Reaction:R-HSA-5655269] Activated FGFR1 mutants bind FRS2 - Homo sapiens
[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2 - Homo sapiens
[Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
[Reaction:R-HSA-5655240] Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
[Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
[Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-1839094] Activated FGFR1 mutants and fusions bind PLCG1 - Homo sapiens
[Reaction:R-HSA-1839098] Activated FGFR1 mutants and fusions phosphorylate PLCG1 - Homo sapiens
[Reaction:R-HSA-1839100] p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2021年12月08日
literatureReference
[LiteratureReference:2045061] FGFR activation in skeletal disorders: too much of a good thing
[LiteratureReference:2045065] Fibroblast growth factor receptors: lessons from the genes
[LiteratureReference:2046359] Syndromic craniosynostosis: from history to hydrogen bonds
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
[LiteratureReference:2023308] A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome
[LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity
[LiteratureReference:1614268] Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines
[LiteratureReference:1614272] Somatic mutations of the protein kinase gene family in human lung cancer
[LiteratureReference:1614246] Comprehensive genomic characterization defines human glioblastoma genes and core pathways
[LiteratureReference:1982006] 8p11 myeloproliferative syndrome: a review
[LiteratureReference:1307938] Fibroblast growth factor signalling: from development to cancer
[LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
maxDepth
4
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Signaling by FGFR1 in disease
normalPathway
[Pathway:R-HSA-5654736] Signaling by FGFR1
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5655302
summation
[Summation:1982034] The FGFR1 gene has been shown to be subject to activating mu...
updateTrackers
[UpdateTracker:9775334] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v79:[updateContainedRLE]
[UpdateTracker:9784649] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9783622] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v56:[addLiteratureReference, modifyText, updateContainedPathway]
Referrals
(updatedInstance)
[UpdateTracker:9775334] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v79:[updateContainedRLE]
[UpdateTracker:9784649] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9783622] Update Tracker - [Pathway:5655302] Signaling by FGFR1 in disease - v56:[addLiteratureReference, modifyText, updateContainedPathway]
(replacementInstances)
[Deleted:6789863] Deletion of instance: 5655311
(hasEvent)
[Pathway:R-HSA-1226099] Signaling by FGFR in disease
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