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Signaling by FGFR4 in disease
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authored
[InstanceEdit:5649623] Rothfels, Karen, 2014年11月20日
created
[InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5655291
deleted
[Deleted:6789864] Deletion of instance: 5655324
disease
[Disease:1500689] cancer
displayName
Signaling by FGFR4 in disease
eventOf
[Pathway:R-HSA-1226099] Signaling by FGFR in disease - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-1839128] FGFR4 mutant receptor activation - Homo sapiens
[Reaction:R-HSA-5655351] Activated FGFR4 mutants bind FRS2 - Homo sapiens
[Reaction:R-HSA-5655284] Activated FGFR4 mutants phosphorylate FRS2 - Homo sapiens
[Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
[Reaction:R-HSA-5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
[Reaction:R-HSA-5655252] Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
[Reaction:R-HSA-5655248] Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
[Reaction:R-HSA-5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-5655313] Activated FGFR4 mutants bind PLCG1 - Homo sapiens
[Reaction:R-HSA-5655341] Activated FGFR4 mutants phosphorylate PLCG1 - Homo sapiens
[Reaction:R-HSA-5655336] p-4Y-PLCG1 dissociates from activated FGFR4 mutants - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2021年12月08日
literatureReference
[LiteratureReference:2038923] Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
[LiteratureReference:1614268] Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines
[LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells
[LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
[LiteratureReference:2045073] Missense FGFR3 mutations create cysteine residues in thanatophoric dwarfism type I (TD1)
[LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
[LiteratureReference:2033248] Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
[LiteratureReference:2045059] Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
[LiteratureReference:2045062] FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer
[LiteratureReference:2045074] The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression
maxDepth
3
modified
[InstanceEdit:9847082] Weiser, Joel, 2023年10月12日
name
Signaling by FGFR4 in disease
normalPathway
[Pathway:R-HSA-5654743] Signaling by FGFR4
releaseDate
2012年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012年05月15日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5655291
summation
[Summation:2045083] FGFR4 is perhaps the least well studied of the FGF receptors...
updateTrackers
[UpdateTracker:9775360] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v79:[updateContainedRLE]
[UpdateTracker:9784612] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
Referrals
(updatedInstance)
[UpdateTracker:9775360] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v79:[updateContainedRLE]
[UpdateTracker:9784612] Update Tracker - [Pathway:5655291] Signaling by FGFR4 in disease - v53:[add_removeHasEvent, add_removeLiteratureReference, add_removeSummation, updateContainedPathway]
(replacementInstances)
[Deleted:6789864] Deletion of instance: 5655324
(hasEvent)
[Pathway:R-HSA-1226099] Signaling by FGFR in disease
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