Reactome Pathway Database

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Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 Show undefined attributes

authored

[InstanceEdit:2105031] Rothfels, K, 2012年02月09日

category binding

compartment

created [InstanceEdit:5655319] Rothfels, Karen, 2014年12月05日

crossReference

dbId 5655348

deleted

[Deleted:5655668] Deletion of instance: 1982082

disease

displayName Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1

edited

[InstanceEdit:2252592] Rothfels, K, 2012年05月16日

entityFunctionalStatus

[EntityFunctionalStatus:9632003] gain_of_function of Activated FGFR4 mutants:p-FRS2 [plasma membrane]

eventOf

[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1

normalReaction [Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1

output

[Complex:R-HSA-5655342] FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2248845] Ezzat, S, 2012年05月15日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-5655348

summation

[Summation:1982079] Activation of FGFR mutants has in some cases been shown to r...

Referrals

(replacementInstances)

[Deleted:5655668] Deletion of instance: 1982082

(hasEvent)

[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease

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