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TUBB

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
For persons named Tubb, see Tubb.
TUBB
Available structures
PDB Ortholog search: PDBe RCSB
List of PDB id codes

3QNZ, 3QO0

Identifiers
Aliases TUBB , CDCBM6, M40, OK/SW-cl.56, TUBB1, TUBB5, CSCSC1, tubulin beta class I
External IDsOMIM: 191130; MGI: 107812; HomoloGene: 69099; GeneCards: TUBB; OMA:TUBB - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human) [1]
Band 6p21.33Start30,717,435 bp [1]
End30,725,538 bp [1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr. Chromosome 17 (mouse)[2]
Band 17|17 B1Start36,144,813 bp [2]
End36,149,198 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • ganglionic eminence

  • ventricular zone

  • smooth muscle tissue

  • stromal cell of endometrium

  • appendix

  • ovary

  • left ovary

  • islet of Langerhans

  • placenta

  • right ovary
  • medial ganglionic eminence

  • saccule

  • otic placode

  • otic vesicle

  • tail of embryo

  • maxillary prominence

  • primitive streak

  • somite

  • mandibular prominence

  • hand
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

203068

22154

Ensembl
ENSG00000196230
ENSG00000232421
ENSG00000183311
ENSG00000224156
ENSG00000235067

ENSG00000232575
ENSG00000227739
ENSG00000229684

ENSMUSG00000001525

UniProt

P07437
Q5SU16

P99024

RefSeq (mRNA)
NM_001293212
NM_001293213
NM_001293214
NM_001293215
NM_001293216

NM_178014

NM_011655

RefSeq (protein)
NP_001280141
NP_001280142
NP_001280143
NP_001280144
NP_001280145

NP_821133
NP_821133.1

NP_035785

Location (UCSC)Chr 6: 30.72 – 30.73 Mb Chr 17: 36.14 – 36.15 Mb
PubMed search[3] [4]
Wikidata

Tubulin beta chain is a protein that in humans is encoded by the TUBB gene.[5] [6] [7]

Interactions

[edit ]

TUBB has been shown to interact with NCOA6 [8] and SYT9.[9]

See also

[edit ]

References

[edit ]
  1. ^ a b c ENSG00000232421, ENSG00000183311, ENSG00000224156, ENSG00000235067, ENSG00000232575, ENSG00000227739, ENSG00000229684 GRCh38: Ensembl release 89: ENSG00000196230, ENSG00000232421, ENSG00000183311, ENSG00000224156, ENSG00000235067, ENSG00000232575, ENSG00000227739, ENSG00000229684Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001525Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Crabtree DV, Ojima I, Geng X, Adler AJ (Aug 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorganic & Medicinal Chemistry. 9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID 11504633.
  6. ^ Volz A, Weiss E, Trowsdale J, Ziegler A (Jan 1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction". Human Genetics. 93 (1): 42–6. doi:10.1007/BF00218911. PMID 8270253. S2CID 7853030.
  7. ^ "Entrez Gene: TUBB tubulin, beta".
  8. ^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670 . PMID 12482968.
  9. ^ Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719 . PMID 12966166.

Further reading

[edit ]
PDB gallery
Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
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Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
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Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman


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