Tubb5 MGI Mouse Gene Detail - MGI:107812 - tubulin, beta 5 class I

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Tubb5 Gene Detail
Summary
  • Symbol
    Tubb5
  • Name
    tubulin, beta 5 class I
  • Synonyms
    B130022C14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107812
    NCBI Gene: 22154
  • Alliance
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36144812-36149193 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107812
protein coding gene Chr17:36144812-36149198 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023654
protein coding gene Chr17:36028577-36032962 (-)
A/J MGP_AJ_G0023609
protein coding gene Chr17:34913769-34918145 (-)
AKR/J MGP_AKRJ_G0023579
protein coding gene Chr17:35339717-35344102 (-)
BALB/cJ MGP_BALBcJ_G0023614
protein coding gene Chr17:35057854-35062230 (-)
C3H/HeJ MGP_C3HHeJ_G0023380
protein coding gene Chr17:35805048-35809433 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024056
protein coding gene Chr17:37499978-37504313 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021534
protein coding gene Chr17:32609735-32614150 (-)
CAST/EiJ MGP_CASTEiJ_G0022871
protein coding gene Chr17:35916075-35920457 (-)
CBA/J MGP_CBAJ_G0023358
protein coding gene Chr17:39081459-39085839 (-)
DBA/2J MGP_DBA2J_G0023482
protein coding gene Chr17:34220173-34224551 (-)
FVB/NJ MGP_FVBNJ_G0023453
protein coding gene Chr17:34016421-34021049 (-)
LP/J MGP_LPJ_G0023562
protein coding gene Chr17:36409115-36413503 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023474
protein coding gene Chr17:37849678-37854074 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024099
protein coding gene Chr17:35654736-35659107 (-)
PWK/PhJ MGP_PWKPhJ_G0022622
protein coding gene Chr17:33081520-33085932 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022441
protein coding gene Chr17:33706097-33710382 (-)
WSB/EiJ MGP_WSBEiJ_G0022937
protein coding gene Chr17:35802876-35807259 (-)



Homology
more
  • Human Ortholog
    TUBB, tubulin beta class I
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBB, tubulin beta class I
  • Synonyms
    CDCBM6, CSCSC1, M40, OK/SW-cl.56, TUBB1, TUBB5
  • Links
    NCBI Gene ID: 203068
    UniProt: P07437

  • Chr Location
    6p21.33; chr6:30717435-30725538 (+) GRCh38
Human Diseases
more
  • Diseases
    1 with Tubb5 mouse models; 2 with human TUBB associations

Human Disease Mouse Models
IDs
microcephaly

DOID:10907
ICD10CM:Q02
ICD9CM_2006:742.1
ICD9CM:742.1
MESH:D008831
NCI:C85874
UMLS_CUI:C0025958

 View 2 models
Mouse Models

Human Disease Modeled: microcephaly

Allelic Composition Genetic Background Reference Phenotypes
Tubb5tm2.1Dak/Tubb5+
Tg(Nes-cre)1Kln/0
 involves: 129P2/OlaHsd * C57BL/6 * SJL J:240157 View
Tubb5tm1.1Dak/Tubb5tm1.1Dak
Tg(Nes-cre)1Kln/0
 involves: 129P2/OlaHsd * C57BL/6 * SJL J:240157 View
IDs
complex cortical dysplasia with other brain malformations 6
IDs
congenital symmetric circumferential skin creases 1
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional knock-in or knock-out allele exhibit microcephaly due to upper-layer loss, delayed cell cycle progression and apoptosis of neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22154 NCBI Gene Model | MGI Sequence Detail 4382 C57BL/6J ± kb
    transcript NM_011655 RefSeq | MGI Sequence Detail 2645 C57BL/6
    polypeptide P99024 UniProt | EBI | MGI Sequence Detail 444 Not Applicable
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 46
      Primer pair 6
      Other 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36389, MGI:2146752, MGI:2146893, MGI:2442353
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:19085 Lewis SA, et al., Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985 Sep;101(3):852-61
    • Latest
      J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531
    TSS for Tubb5:
    (View these features in JBrowse)
    Transcription Start Site Location Distance from Gene 5'-end
    Tssr147909 Chr17:36149151-36149156 (-) 39 bp
    Tssr147908 Chr17:36149111-36149135 (-) 70 bp
    Tssr147907 Chr17:36147923-36147970 (-) 1,246 bp
    Tssr147906 Chr17:36147579-36147623 (-) 1,592 bp
    Tssr147905 Chr17:36147097-36147173 (-) 2,058 bp
    Tssr147904 Chr17:36146893-36146925 (-) 2,284 bp
    Tssr147903 Chr17:36146862-36146892 (-) 2,316 bp
    Tssr147902 Chr17:36146823-36146858 (-) 2,352 bp
    Tssr147901 Chr17:36146802-36146819 (-) 2,382 bp
    Tssr5111 Chr17:36146756-36146793 (-) 2,418 bp
    Tssr5110 Chr17:36146725-36146747 (-) 2,457 bp
    Tssr147900 Chr17:36146695-36146706 (-) 2,492 bp
    Tssr147899 Chr17:36146654-36146675 (-) 2,528 bp
    Tssr147898 Chr17:36146518-36146596 (-) 2,636 bp
    Tssr147897 Chr17:36146463-36146509 (-) 2,707 bp
    Tssr147896 Chr17:36146426-36146459 (-) 2,750 bp
    Tssr147895 Chr17:36146388-36146412 (-) 2,793 bp
    Tssr147894 Chr17:36146334-36146372 (-) 2,840 bp
    Tssr147893 Chr17:36146277-36146305 (-) 2,902 bp
    Tssr147892 Chr17:36146022-36146087 (-) 3,138 bp
    Tssr147891 Chr17:36145787-36145890 (-) 3,354 bp
    Tssr147890 Chr17:36145632-36145736 (-) 3,509 bp
    Tssr147889 Chr17:36145583-36145592 (-) 3,605 bp
    Tssr147888 Chr17:36145481-36145507 (-) 3,699 bp
    Tssr147887 Chr17:36145368-36145386 (-) 3,816 bp
    Tssr147886 Chr17:36145256-36145284 (-) 3,923 bp
    Tssr147885 Chr17:36145218-36145233 (-) 3,967 bp
    Tssr147884 Chr17:36144937-36144965 (-) 4,242 bp
    Tssr147883 Chr17:36144865-36144866 (-) 4,327 bp
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support. last database update
    10/07/2025
    MGI 6.24 The Jackson Laboratory
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