JWH-098
| Legal status | |
|---|---|
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C26H27NO2 |
| Molar mass | 385.507 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around tenfold selective for CB1 over CB2, in JWH-098 this is reversed, and it is around four times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding.[2]
Legal status
[edit ]In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-098 are Schedule I Controlled Substances.[3]
JWH-098 is illegal in Russia,[4] Sweden,[5] and the UK,[6] although it is unclear whether it has any history of human use.
See also
[edit ]References
[edit ]- ^ Anvisa (2023年07月24日). "RDC No 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023年07月25日). Archived from the original on 2023年08月27日. Retrieved 2023年08月27日.
- ^ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, et al. (January 2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic & Medicinal Chemistry. 13 (1): 89–112. doi:10.1016/j.bmc.2004年09月05日0. PMID 15582455.
- ^ 21 U.S.C. § 812 : Schedules of controlled substances
- ^ "Постановление от 31 декабря 2009 г. No 1186 О внесении изменений в некоторые постановления Правительства Российской Федерации по вопросам, связанным с оборотом наркотических средств". Government.ru. Archived from the original on 2010年09月29日. Retrieved 2010年09月09日.
- ^ Svensk författningssamling
- ^ The Misuse of Drugs Act 1971 (Amendment) Order 2009 Archived 2009年11月03日 at the Wayback Machine
This cannabinoid related article is a stub. You can help Wikipedia by expanding it.