2-Hydroxysaclofen
From Wikipedia, the free encyclopedia
Chemical compound, GABA(B) receptor antagonist
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| IUPAC name
3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
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3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C9H12ClNO4S | |
| Molar mass | 265.71 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
2-Hydroxysaclofen is a GABAB receptor antagonist and an analogue of saclofen.
Pharmacodynamics
[edit ]2-Hydroxysaclofen binds to the GABAB receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABAB protein.[1]
2-Hydroxysaclofen has been reported to be more potent than saclofen.[2]
See also
[edit ]- Saclofen - another GABAB receptor antagonist
- Baclofen - an agonist of the receptor
References
[edit ]- ^ "2 Hydroxysaclofen - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2024年02月03日.
- ^ "2-Hydroxysaclofen".