Laboratory of Biomolecular Research (LBR)

LBR Hero

The PSI Laboratory of Biomolecular Research studies the structure and dynamics of proteins on the atomic level by state-of-the-art structural biology techniques at Swiss Universities and the X-ray large research facilities of PSI.

More about us

LBR research topics

Biomolecular Complexes

Regulation of microtubule structure, function and dynamics by proteins and drugs

Structural Biology of Membrane Proteins

G-protein coupled receptors (GPCRs) and their signaling complexes

Protein Engineering

Structural studies of proteins that are relevant for infectious diseases

Time-Resolved Structural Biology

Dynamics of soluble and membrane proteins using XFEL and synchrotron X-ray radiation sources

Mechanisms of Signal Transduction

Structure-function relationship of membrane proteins involved in transmembrane and intracellular signaling

Lab News & Scientific Highlights

Researchers deciphered the structure of an ion channel from the rod cells of the eye (shown in blue) while it interacts with the protein calmodulin (purple).

04.04.2023

•8 min

Calcium sensor helps us to see the stars

New insight into how the protein calmodulin interacts with an ion channel in the eye could explain how our eyes achieve remarkable sensitivity to dim light.

Rhodopsin

22.03.2023

•Grundlagen der Natur

•8 min

So beginnt das Sehen

Further information aboutSwissFEL

Further information aboutBiologie

PSI-Forschende haben untersucht, was als Allererstes im Auge abläuft, wenn Licht auf die Netzhaut trifft.

Medikamente mit Licht an- und abschalten

20.02.2023

•Health Innovation

•9 min

Medikamente mit Licht an- und abschalten

Further information aboutSwissFEL

Further information aboutSLS

Further information aboutMedizin

Forschende des PSI drehen einen molekularen Film eines Krebsmedikaments mit Lichtschalter. Das eröffnet neue Einblicke für Wirkstoffentwickler.

More Highlights

Publications

Albà A, Adelmann A, Rochman D
Uncertainty quantification of spent nuclear fuel with multifidelity Monte Carlo
Annals of Nuclear Energy. 2025; 211: 110892 (17 pp.). https://doi.org/10.1016/j.anucene.2024.110892
DORA PSI
Cherezov A, Vasiliev A, Ferroukhi H
Application of backward differential formula and Anderson's method for multigroup diffusion transient equation
Annals of Nuclear Energy. 2025; 210: 110837 (19 pp.). https://doi.org/10.1016/j.anucene.2024.110837
DORA PSI
Rochman D, Koning A, Goriely S, Hilaire S
TENDL-astro: a new nuclear data set for astrophysics interest
Nuclear Physics A. 2025; 1053: 122951 (11 pp.). https://doi.org/10.1016/j.nuclphysa.2024.122951
DORA PSI