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Rita1791 / Elephant-TP53-Hotspot-Mapping

Star 3

Reproducible comparative genomics study investigating human TP53 cancer mutation hotspots across elephant TP53-related sequences, integrating sequence conservation, phylogenetic analysis, computational prioritization, and research software to explore evolutionary conservation of cancer-associated residues.

machine-learning bioinformatics reproducible-research computational-biology phylogenetics cancer-genomics comparative-genomics sequence-analysis protein-analysis research-software p53 cancer-biology tp53 elephant-genomics

Updated Aug 18, 2026
Python

Rita1791 / TP53-Evolutionary-Conservation-Mammals

Star 2

Comparative evolutionary analysis of recurrent human TP53 cancer mutation hotspots across 56 mammalian species, integrating residue-level conservation, statistical testing, phylogenetic analysis, and cancer-associated mutation data to investigate evolutionary constraints on clinically relevant TP53 residues.

bioinformatics reproducible-research computational-biology phylogenetics cancer-genomics comparative-genomics cancer-research protein-evolution sequence-analysis evolutionary-biology p53 cancer-biology tp53 mammalian-genomics

Updated Aug 18, 2026
Jupyter Notebook

Rita1791 / ritika_rawat.github.io

Star 2

Academic research portfolio of Ritika Rajendra Rawat, focused on computational biology, evolutionary cancer genomics, comparative TP53 genomics, WGS benchmarking, and experimental analytical sciences.

github-pages portfolio bioinformatics computational-biology cancer-genomics comparative-genomics variant-calling wgs tp53 academic-portfolio

Updated Aug 27, 2026
HTML

clintval / tp53

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Tools for programmatically annotating VCFs with the Seshat TP53 database

mutation vcf seshat tp53

Updated Dec 16, 2024
Scala

lerivera27 / GDC-data_commons

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Find tumor gene mutation rates (TP53 and STAT5A) using cancer datasets from The Cancer Genome Atlas.

bash-script brca tp53 tcga-dataset stat5a

Updated Apr 9, 2025

adarboleda6 / ProyectoFinal2024

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Proyecto final de la clase de Bioinformática

primates tp53

Updated Jun 27, 2024

ghoshparnabali / Tumour-Only-Somatic-Variant-Calling-in-Triple-Negative-Breast-Cancer-Whole-Exome-Sequencing

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This repository contains an end-to-end tumour-only somatic variant-calling pipeline (GATK Mutect2 + snpEff) for triple-negative breast cancer whole-exome data, focused on BRCA1/BRCA2/TP53, built on Google Colab via Visual Studio Code.

bioinformatics ngs visual-studio-code cancer-genomics multiqc variant-calling somatic-mutations wes bwa-mem whole-exome-sequencing breast-cancer snpeff mutect2 fastqc google-colab gatk4 sra-toolkit tp53 brca2 brca1

Updated Jul 6, 2026
HTML

ricky-madison / TP53-Mutation-Ranker

Star 0

A precision oncology dashboard for ranking and prioritizing TP53 cancer mutations by druggability. Integrates structural biology, quantum chemistry (IBM), and clinical trial data to identify the most promising targets for small-molecule therapy development.

cancer mutation oncology tp53