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Osaterone

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Chemical compound
This article is about a non-clinically used antiandrogen compound. For the pharmaceutical drug, see osaterone acetate.
Pharmaceutical compound
Osaterone
Clinical data
Other namesTZP-5258; Gestoxarone; 2-Oxachloromadinone; 17α-Hydroxy-6-chloro-2-oxa-6-dehydroprogesterone; 17α-Hydroxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione
ATCvet code
Identifiers
  • (1R,3aS,3bR,9aR,9bS,11aS)-1-acetyl-5-chloro-1-hydroxy-9a,11a-dimethyl-2,3,3a,3b,9,9b,10,11-octahydroindeno[4,5-h]isochromen-7-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C20H25ClO4
Molar mass 364.87 g·mol−1
3D model (JSmol)
  • CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)OC[C@]34C)Cl)C)O
  • InChI=1S/C20H25ClO4/c1-11(22)20(24)7-5-14-12-8-16(21)15-9-17(23)25-10-18(15,2)13(12)4-6-19(14,20)3/h8-9,12-14,24H,4-7,10H2,1-3H3/t12-,13+,14+,18-,19+,20+/m1/s1
  • Key:ZLLOIFNEEWYATC-XMUHMHRVSA-N

Osaterone (developmental code name TZP-5258), also known as 17α-hydroxy-6-chloro-2-oxa-6-dehydroprogesterone, as well as 2-oxachloromadinone, is a steroidal antiandrogen and progestin that was never marketed.[1] [2] The C17α acetate ester of osaterone, osaterone acetate, in contrast, has been marketed.[1] [2]

References

[edit ]
AR Tooltip Androgen receptor
Agonists
SARMs Tooltip Selective androgen receptor modulator
Antagonists
GPRC6A
Agonists
PR Tooltip Progesterone receptor
Agonists
Mixed
(SPRMs Tooltip Selective progesterone receptor modulators)
Antagonists
mPR Tooltip Membrane progesterone receptor
(PAQR Tooltip Progestin and adipoQ receptor)
Agonists
Antagonists


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