20α-Dihydrodydrogesterone
From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
| Clinical data | |
|---|---|
| Other names | 20α-DHD; 20α-Hydroxydydrogesterone; 20(S)-Hydroxy-9β,10α-pregna-4,6-dien-3-one |
| Drug class | Progestin; Progestogen |
| Pharmacokinetic data | |
| Elimination half-life | 14–17 hours[1] |
| Excretion | Urine (mainly as glucuronide conjugates) |
| Identifiers | |
| |
| CAS Number |
|
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C21H30O2 |
| Molar mass | 314.469 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
20α-Dihydrodydrogesterone (20α-DHD), also known as 20α-hydroxydydrogesterone, as well as 20(S)-hydroxy-9β,10α-pregna-4,6-dien-3-one, is a progestin and the major active metabolite of dydrogesterone.[2] [1] [3] It appears that dydrogesterone is a prodrug of 20α-DHD, as it is largely transformed into this metabolite when given orally in humans.[3] 20α-DHD has progestogenic activity similarly to dydrogesterone, but is far less potent in comparison.[3]
See also
[edit ]References
[edit ]- ^ a b Bińkowska M, Woroń J (June 2015). "Progestogens in menopausal hormone therapy". Przeglad Menopauzalny = Menopause Review. 14 (2): 134–143. doi:10.5114/pm.2015.52154. PMC 4498031 . PMID 26327902.
- ^ Olbrich M, Weigl K, Kahler E, Mihara K (October 2016). "Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 46 (10): 868–874. doi:10.3109/00498254.2015.1134852. PMID 26796435. S2CID 22311056.
- ^ a b c Rižner TL, Brožič P, Doucette C, Turek-Etienne T, Müller-Vieira U, Sonneveld E, et al. (May 2011). "Selectivity and potency of the retroprogesterone dydrogesterone in vitro". Steroids. 76 (6): 607–615. doi:10.1016/j.steroids.2011年02月04日3. PMID 21376746. S2CID 31609405.
Stub icon
This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.