KCNA6

Protein-coding gene in humans

KCNA6

Identifiers

KCNA6 , HBK2, KV1.6, PPP1R96, potassium voltage-gated channel subfamily A member 6

External IDs

OMIM: 176257; MGI: 96663; HomoloGene: 1684; GeneCards: KCNA6; OMA:KCNA6 - orthologs

Gene location (Human)
Chromosome 12 (human)
Chr.	Chromosome 12 (human) ^[1]
Chromosome 12 (human) Genomic location for KCNA6 Genomic location for KCNA6
Band	12p13.32	Start	4,809,334 bp ^[1]
Band	12p13.32	End	4,813,318 bp ^[1]

Gene location (Mouse)
Chromosome 6 (mouse)
Chr.	Chromosome 6 (mouse)^[2]
Chromosome 6 (mouse) Genomic location for KCNA6 Genomic location for KCNA6
Band	6 F3\|6 61.72 cM	Start	126,685,292 bp ^[2]
Band	6 F3\|6 61.72 cM	End	126,717,637 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in testicle prefrontal cortex islet of Langerhans ventricular zone Brodmann area 9 Achilles tendon cingulate gyrus right frontal lobe anterior cingulate cortex ganglionic eminence	Top expressed in dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion medial dorsal nucleus superior frontal gyrus lateral hypothalamus globus pallidus primary visual cortex medial vestibular nucleus trigeminal ganglion cerebellar cortex
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ion channel activity potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity
Cellular component	axon terminus integral component of membrane voltage-gated potassium channel complex axon plasma membrane potassium channel complex integral component of plasma membrane membrane
Biological process	potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3742


16494

Ensembl


ENSG00000151079


ENSMUSG00000038077

UniProt


P17658


Q61923

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12: 4.81 – 4.81 Mb

Chr 6: 126.69 – 126.72 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily A member 6 also known as K_v1.6 is a protein that in humans is encoded by the KCNA6 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151079 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038077 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels" (PDF). Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

External links

[edit ]

Kv1.6+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
KCNA6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v
t
e

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

v
t
e

Retrieved from "https://en.wikipedia.org/w/index.php?title=KCNA6&oldid=1168214299"

References

Further reading

External links