CACNA2D2

Protein-coding gene in humans

CACNA2D2

Identifiers

CACNA2D2 , CACNA2D, calcium voltage-gated channel auxiliary subunit alpha2delta 2, CASVDD

External IDs

OMIM: 607082; MGI: 1929813; HomoloGene: 4400; GeneCards: CACNA2D2; OMA:CACNA2D2 - orthologs

Gene location (Human)
Chromosome 3 (human)
Chr.	Chromosome 3 (human) ^[1]
Chromosome 3 (human) Genomic location for CACNA2D2 Genomic location for CACNA2D2
Band	3p21.31	Start	50,362,613 bp ^[1]
Band	3p21.31	End	50,504,244 bp ^[1]

Gene location (Mouse)
Chromosome 9 (mouse)
Chr.	Chromosome 9 (mouse)^[2]
Chromosome 9 (mouse) Genomic location for CACNA2D2 Genomic location for CACNA2D2
Band	9 F1\|9 58.02 cM	Start	107,276,811 bp ^[2]
Band	9 F1\|9 58.02 cM	End	107,406,542 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in lower lobe of lung cerebellar vermis superior vestibular nucleus ventral tegmental area upper lobe of lung upper lobe of left lung right lung vena cava right hemisphere of cerebellum gonad	Top expressed in lateral septal nucleus habenula trigeminal ganglion substantia nigra lateral hypothalamus motor neuron mammillary body supraoptic nucleus lobe of cerebellum atrium
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	calcium channel activity metal ion binding voltage-gated ion channel activity voltage-gated calcium channel activity
Cellular component	voltage-gated calcium channel complex integral component of membrane membrane plasma membrane
Biological process	regulation of multicellular organism growth regulation of insulin secretion regulation of ion transmembrane transport positive regulation of organ growth ion transport neuromuscular junction development calcium ion transmembrane transport rhythmic synaptic transmission calcium ion transport cardiac conduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9254


56808

Ensembl


ENSG00000007402


ENSMUSG00000010066

UniProt


Q9NY47


Q6PHS9

RefSeq (mRNA)

NM_001005505
NM_001174051
NM_001291101
NM_006030

NM_001174047
NM_001174048
NM_001174049
NM_001174050
NM_020263

RefSeq (protein)

NP_001005505
NP_001167522
NP_001278030
NP_006021

NP_001167518
NP_001167519
NP_001167520
NP_001167521
NP_064659

Location (UCSC)

Chr 3: 50.36 – 50.5 Mb

Chr 9: 107.28 – 107.41 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.^[5]

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.^[5]

CACNA2D2 containing channels are blocked by amiodarone.^[6]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007402 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2".
^ "Amiodarone". Drugbank. Retrieved 2019年05月28日.

External links

[edit ]

CACNA2D2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CACNA2D2 genome location and CACNA2D2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v
t
e

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

Retrieved from "https://en.wikipedia.org/w/index.php?title=CACNA2D2&oldid=1241709021"

CACNA2D2

See also

References

Further reading

External links