Coriamyrtin
From Wikipedia, the free encyclopedia
Convulsant toxin
| Names | |
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| IUPAC name
(1S,2R,3S,5R,6R,7R,9S,12R)-2-Hydroxy-7-methyl-12-prop-1-en-2-ylspiro[4,10-dioxatetracyclo[7.2.1.02,7.03,5]dodecane-6,2'-oxirane]-11-one
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| Other names
Coriamyrtine
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C15H18O5 | |
| Molar mass | 278.304 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Coriamyrtin is a toxic γ-lactone naturally present in a multitude of plants.
Natural occurrence
[edit ]Coriamyrtin can be found in Scurrula parasitica ,[2] Coriaria microphylla ,[3] and certain other plants.
Toxicity
[edit ]Coriamyrtin is a convulsant.[4] It appears to act via antagonism of GABAA receptors.[5] Poisoning is usually from ingestion of parts of the plants containing it. A case of poisoning was able to be treated with repeated administration of diazepam, an anticonvulsant.[6]
References
[edit ]- ^ "Coriamyrtin".
- ^ PubChem. "Scurrula parasitica". pubchem.ncbi.nlm.nih.gov. Retrieved 2024年02月11日.
- ^ PubChem. "Coriaria microphylla". pubchem.ncbi.nlm.nih.gov. Retrieved 2024年02月11日.
- ^ "T3DB: Coriamyrtin". www.t3db.ca. Retrieved 2024年02月11日.
- ^ Pérez, Claudia; Becerra, José; Manríquez-Navarro, Paula; Aguayo, Luis Gerardo; Fuentealba, Jorge; Guzmán, José Leonardo; Joseph-Nathan, Pedro; Jiménez, Verónica; Muñoz, Marcelo Andrés; Silva, Mario (2011). "Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia". Chemical & Pharmaceutical Bulletin. 59 (2): 161–165. doi:10.1248/cpb.59.161. ISSN 1347-5223. PMID 21297293.
- ^ de Haro, Luc; Pommier, Philip; Tichadou, Lucia; Hayek-Lanthois, Maryvonne; Arditti, Jocelyne (November 2005). "Poisoning by Coriaria myrtifolia Linnaeus: a new case report and review of the literature". Toxicon. 46 (6): 600–603. Bibcode:2005Txcn...46..600D. doi:10.1016/j.toxicon.2005年06月02日6. ISSN 0041-0101. PMID 16165183.
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