4-Fluorophenibut
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| Other names | CGP-11130; β-(4-Fluorophenyl)-γ-aminobutyric acid; β-(4-Fluorophenyl)-GABA; Baflofen; Fluorophenibut; F-Phenibut; Fluoribut |
| Routes of administration | Oral |
| Drug class | GABAB receptor agonist |
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| Chemical and physical data | |
| Formula | C10H12FNO2 |
| Molar mass | 197.209g·mol−1 |
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4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABAB receptor agonist which was never marketed.[1] It is selective for the GABAB receptor over the GABAA receptor (IC50 = 1.70 μM and> 100 μM, respectively).[1] The drug is a GABA analogue and is closely related to baclofen (β-(4-chlorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), and phenibut (β-phenyl-GABA).[1] It is less potent as a GABAB receptor agonist than baclofen but more potent than phenibut.[1]
The substance is sometimes referred to as 4F-phenibut, F-phenibut, or baflofen, and colloquially as fluorobut.
Legal status
[edit ]F-Phenibut is a prohibited substance in Lithuania[2] and Hungary.[3]
References
[edit ]- 1 2 3 4 Bowery NG, Hill DR, Hudson AL (1983). "Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes". Br. J. Pharmacol. 78 (1): 191–206. doi:10.1111/j.1476-5381.1983.tb09380.x. PMC 2044790 . PMID 6297646.
- ↑ "RINKOS RIBOJIMO PRIEMONĖS FENIBUTUI!". ntakd.lrv.lt (in Lithuanian). Archived from the original on 2021年10月06日. Retrieved 2020年01月27日.
- ↑ MAGYARORSZÁG HIVATALOS LAPJA. Retrieved 2021年04月28日.
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