No. RPM is good at managing the core software of a distro. It's fast, well understood and supports features like prepatching of sources. What RPM is not good at is non-core packages, ie programs available from the net, from commercial vendors, magazine coverdisks and so on. This is the area that autopackage tackles. Although in theory it'd be possible to build a distro based around it, in reality such a solution would be very suboptimal as we sacrifice speed for flexibility and distro neutrality. For instance, it can take several seconds to verify the presence of all required dependencies, something that RPM can do far quicker.
[^] # Re: La solution ? Pas vraiment...
Posté par liberforce (site web personnel, Mastodon) . En réponse au journal Distributions Linux, vers un éclatement des formats de paquetages ?. Évalué à 4.
http://autopackage.org/faq.html
Donc non, autopackage n'est pas la solution.