C. albicans MCM1/C7_00890C Summary

Last curated 2024年07月24日
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Summary
Locus History Literature Gene Ontology Phenotype Homologs Protein
MCM1 BASIC INFORMATION [ View References ]
Standard Name MCM11
Systematic Name, Reference Strain C7_00890C_A (C. albicans SC5314)
Assembly 19/21 Identifier orf19.7025
Alias IPF2363.12 , Contig4-3091_00133 , Contig4-3091_00143 , orf6.79514 , CA52092 , CaJ7.01075 , CaO19.70256 , CaO19_70256 , CaJ7_01076 , orf19.7025, C7_00890C_B, C7_00890C
Feature Type ORF, Verified
Description Transcription factor; regulator of hyphal growth; may act with Wor1p; canonical and non-canonical binding sites; MADS domain DNA-binding motif; similar to S. cerevisiae Mcm1p; greater expression in white than opaque cells; intron in 5'-UTR (1, 7, 8, 9, 10)
Literature
Allele Name C7_00890C_B
Allelic Variation No allelic variation in feature
CUG Codons C7_00890C_A: 1
C7_00890C_B: 1
Systematic Names Used in Other Strains CAWG_05447 (C. albicans WO-1)
Orthologous genes in Candida species C. auris B8441 Ortholog(s) : B9J08_003278
C. parapsilosis CDC317 Ortholog(s) : CPAR2_301420
C. dubliniensis CD36 Ortholog(s) : Cd36_70830
C. glabrata CBS138 Ortholog(s) : CAGL0F06237g
View ortholog cluster : 19 genes among 19 Candida-related species/strains
Ortholog(s) in non-CGD species S. cerevisiae (MCM1)
Best hit(s) in non-CGD species A. nidulans (mcmA) ; N. crassa (NCU07430) ; S. pombe (SPAC11E3.06)
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GO Annotations View all MCM1 GO evidence and references

Molecular Function
Manually curated * DNA binding (IDA)
* DNA-binding transcription factor activity (ISS)
Computational * cis-regulatory region sequence-specific DNA binding (IEA with EBI: MADS SRF-like)
* protein dimerization activity (IEA with EBI: Transcription factor, MADS-box, EBI: Transcription factor, MADS-box superfamily)

Biological Process
Manually curated * DNA damage response (IDA)
* filamentous growth (IMP)
* filamentous growth of a population of unicellular organisms (IMP)
* positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter (IMP, IGI)
* regulation of pseudohyphal growth (IMP, IGI)
* regulation of transcription by RNA polymerase II (ISS)
High-throughput * regulation of DNA-templated transcription (ISS)

Cellular Component
Manually curated * chromatin (IDA)
Mutant Phenotype View all MCM1 Phenotype details and references
Classical genetics
homozygous null * HOF1 accumulation: decreased
* inviable

overexpression * HOF1 accumulation: increased
* flocculation: increased
* hyphal growth: increased

repressible * filamentous growth: abnormal

Large-scale survey
heterozygous null * invasive growth: decreased

homozygous null * biofilm formation: normal
* viable

null * inviable

Sequence Information Ca22chr7A_C_albicans_SC5314:188811 to 188023 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2014年06月24日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to789188,811to188,0232014年06月24日2014年06月24日

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Sequence Analysis Tools
Maps & Displays
Sequence Information Ca22chr7A_C_albicans_SC5314:188811 to 188023 | JBrowse
Note: this feature is encoded on the Crick strand.
Allele Location
Allele C7_00890C_B 		Ca22chr7B_C_albicans_SC5314:188810 to 188022 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2014年06月24日 | Sequence: 2014年06月24日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to789188,810to188,0222014年06月24日2014年06月24日

Allele Location
Allele C7_00890C_B Ca22chr7B_C_albicans_SC5314:188810 to 188022 | JBrowse
Note: this feature is encoded on the Crick strand.
External Links BioGRID | CGOB | Entrez Gene (1, 2) | Fungal Orthologs | FungiDB | GenBank (1, 2, 3, 4, 5) | Non-periodic Expression | Pedant | PhylomeDB | SwissProt | TrEMBL
Primary CGDID CAL0000194125
ADDITIONAL INFORMATION for MCM1
Gene/Sequence Resources
LOCUS SUMMARY NOTES for MCM1 (Last Updated: 2011年06月10日)
  • Mcm1p is a MADS box family transcription factor that regulates morphogenesis of C. albicans (1)
  • similar to S. cerevisiae Mcm1p which is involved in cell-type-specific transcription and pheromone response, it is recruited to target promoters by additional transcription factors
  • it is an essential gene in C. albicans (1)
  • Mcm1p transcript levels do not change significantly, independent of media, cell type or temperature and respond to an autoregulatory feedback mechanism; it is thought that Mcm1p activity is regulated by post-translational modifications (1)
  • both overexpression and repression of this gene leads to the induction of hyphal growth (1)
  • may act in concert with Wor1p; Mcm1p binds, in combination with the regulator Wor1p, at many genes that function in processes associated with adaptation to the human host, including the white-opaque epigenetic switch (10)
  • in a complex with the transcription factor, Ahr1p, the Ahr1p-Mcm1p complex directly activates adhesion genes such as ALS1, ALS2, ALS4 and CSH1 (11)
  • it has greater levels of white-phase expression and low levels of opaque-phase expression (7)
  • contains an unannotated intron in its 5'-UTR (9)
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MCM1]
1) Rottmann M, et al. (2003) A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis. Mol Microbiol 47(4):943-59
CGD Papers Entry Pubmed Entry Reference LINKOUT
2) CandidaDB
CGD Papers Entry
3) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19.
CGD Papers Entry
4) CGD (2005) CGD comparison of orf6 and orf19 predicted protein products.
CGD Papers Entry
5) Chibana H, et al. (2005) Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome. Genetics 170(4):1525-37
CGD Papers Entry Pubmed Entry Reference LINKOUT
6) Maglott D, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 35(Database issue):D26-31
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7) Srikantha T, et al. (2001) The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans. J Bacteriol 183(15):4614-25
CGD Papers Entry Pubmed Entry Reference LINKOUT
8) Nobile CJ and Mitchell AP (2005) Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p. Curr Biol 15(12):1150-5
CGD Papers Entry Pubmed Entry Reference LINKOUT Web Supplement Data
9) Mitrovich QM, et al. (2007) Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans. Genome Res 17(4):492-502
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10) Tuch BB, et al. (2008) The evolution of combinatorial gene regulation in fungi. PLoS Biol 6(2):e38
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11) Askew C, et al. (2011) The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion. Mol Microbiol 79(4):940-53
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