Systematic Name, Reference Strain C7_00090C_A (C. albicans SC5314) |
|
Alias WAP12 orf6.8439 3 , IPF5641.1 3 , Contig4-2995_0015 4 , CA5585 3 , CaJ7.0015 5 , CaO19_7114 6 , CaJ7_0015 6 , CaO19.7114 6 , orf19.7114, C7_00090C_B, C7_00090C |
Feature Type ORF, Verified |
Description Surface antigen on elongating hyphae and buds; strain variation in repeat number; ciclopirox, filament induced, alkaline induced by Rim101; Efg1-, Cph1, Hap43-regulated; required for WT RPMI biofilm formation; Bcr1-induced in a/a biofilms ( 1, 2, 7, 8, 9, 10, 11, 12) |
Name Description Candida Surface Antigen 1 |
Allele Name C7_00090C_B |
Allelic Variation No allelic variation in feature |
CUG Codons C7_00090C_A: 0
C7_00090C_B: 0 |
Systematic Names Used in Other Strains CAWG_05366 (C. albicans WO-1) |
|
|
JBrowse
JBrowse for feature C7_00090C_A
|
Molecular Function
Biological Process
Cellular Component |
Classical genetics Large-scale survey |
| Sequence Information | Ca22chr7A_C_albicans_SC5314:13080 to 10024 | JBrowse
Note: this feature is encoded on the Crick strand. | | Last Update | Coordinates: 2014年06月24日 | Sequence: 2014年06月24日 | | Subfeature Details | | | Relative
Coordinates | | Chromosomal
Coordinates | | Most Recent Update |
|---|
| Coordinates | | Sequence | | CDS | | 1 | to | 3057 | | 13,080 | to | 10,024 | | 2014年06月24日 | | 2014年06月24日 |
| |
|
Sequence Information Ca22chr7A_C_albicans_SC5314:13080 to 10024 | JBrowse Note: this feature is encoded on the Crick strand. |
Allele Location
Allele C7_00090C_B | Ca22chr7B_C_albicans_SC5314:13080 to 10024 | JBrowse
Note: this feature is encoded on the Crick strand. | | Last Update | Coordinates: 2014年06月24日 | Sequence: 2014年06月24日 | | Subfeature Details | | | Relative
Coordinates | | Chromosomal
Coordinates | | Most Recent Update |
|---|
| Coordinates | | Sequence | | CDS | | 1 | to | 3057 | | 13,080 | to | 10,024 | | 2014年06月24日 | | 2014年06月24日 |
|
|
Allele Location
Allele C7_00090C_B Ca22chr7B_C_albicans_SC5314:13080 to 10024 | JBrowse Note: this feature is encoded on the Crick strand. |
|
Primary CGDID CAL0000201940 |
ADDITIONAL INFORMATION for CSA1 |
LOCUS SUMMARY NOTES for CSA1 (Last Updated: 2011年05月12日) - Csa1p (Candida Surface Antigen 1), also called Wap1p, is an antigen present on the surface of elongating hyphae and growing buds; it has been described as a member of a haemoglobin-receptor gene family comprised of the genes RBT5, RBT51, CSA1, CSA2 and PGA7 (1)
- the primary amino acid sequence of Csa1p reveals the presence of repeated, nearly identical, cysteine-rich hydrophobic domains that are separated by acidic, proline-rich hydrophilic domains composed of two repetitive units, TSAP and P(S/A/V)ETSS(E/Q) that show significant sequence similarity to motifs found in other cell surface proteins; the N- and C-termini contain a core of hydrophobic residues, which may function as a signal sequence for secretion and a GPI-anchoring determinant, respectively; fungal extracellular membrane (CFEM) protein; the number of repeat domains vary by strain (1, 13)
- it shares sequence similarity with C. albicans Rbt5p (2)
- CSA1 is located on chromosome 7 (14)
- it is preferentially expressed during the mycelial growth phase; low levels of transcript are detected in the yeast form (1)
- the mutant has no obvious defects in hyphal growth (1)
- it is repressed by the transcriptional regulator, Tup1p (2)
- alkaline pH-regulated gene; expression is greater at pH 8 than at pH 4; it is positively regulated by Rim101p, a transcription factor involved in the alkaline pH response; one consensus binding site for Rim101p is present in the CSA1 promoter (8, 9)
- both of the transcription factors, EFG1 and CPH1, are required for proper transcriptional regulation of CSA1 (7)
- gene expression is induced by exposure to the synthetic antifungal drug, ciclopirox (10)
|
1) Lamarre C, et al. (2000) Expression cloning of the Candida albicans CSA1 gene encoding a mycelial surface antigen by sorting of Saccharomyces cerevisiae transformants with monoclonal antibody-coated magnetic beads. Mol Microbiol 35(2):444-53 CGD Papers Entry Pubmed Entry Reference LINKOUT 4) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19. CGD Papers Entry 5) Chibana H, et al. (2005) Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome. Genetics 170(4):1525-37 CGD Papers Entry Pubmed Entry Reference LINKOUT 10) Sigle HC, et al. (2005) Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. J Antimicrob Chemother 55(5):663-73 CGD Papers Entry Pubmed Entry Reference LINKOUT 11) Singh RP, et al. (2011) Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans. J Biol Chem 286(28):25154-70 CGD Papers Entry Pubmed Entry Reference LINKOUT Data 12) Srikantha T, et al. (2013) Identification of genes upregulated by the transcription factor Bcr1 that are involved in impermeability, impenetrability, and drug resistance of Candida albicans a/alpha biofilms. Eukaryot Cell 12(6):875-88 CGD Papers Entry Pubmed Entry Reference LINKOUT |
CGD Copyright © 2004-2025 The Board of Trustees, Leland Stanford Junior University.Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied.
To cite CGD, please use the following
reference: Skrzypek MS, Binkley J, Binkley G, Miyasato SR, Simison M, Sherlock G (2017). The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data.
Nucleic Acids Res 45 (D1); D592-D596; see
How to cite CGD.