C. albicans CDC24/C5_01970C Summary

Last curated 2025年05月29日
See the Literature Guide for most recent publications.

Summary

Locus History Literature Gene Ontology Phenotype Homologs Protein

CDC24 BASIC INFORMATION [ View References ]

Standard Name CDC24¹

Systematic Name, Reference Strain C5_01970C_A (C. albicans SC5314)

Assembly 19/21 Identifier orf19.3174

Alias orf19.10684, IPF19624.1², IPF19625.1², Contig4-2507_0005³, orf6.1241⁴, orf6.1482⁴, CA0509², CaO19.3174⁵, orf19.3174, C5_01970C_B, C5_01970C

Feature Type ORF, Verified

Description GDP-GTP exchange factor for Cdc42p; phosphorylated; required for maintenance of hyphal growth; misexpression blocks hyphal growth and causes avirulence in a mouse model of systemic infection; antigenic during human oral infection (6, 7, 8)

Allele Name C5_01970C_B

Allelic Variation Non-synonymous variation between alleles
Sequence variation between alleles within 100 bp upstream of feature start coordinates
Sequence variation between alleles within 100 bp downstream of feature end coordinates

CUG Codons C5_01970C_A: 4
C5_01970C_B: 4

Systematic Names Used in Other Strains CAWG_04582 (C. albicans WO-1)

Orthologous genes in Candida species C. parapsilosis CDC317 Ortholog(s) : CPAR2_303780
C. dubliniensis CD36 Ortholog(s) : Cd36_51820
C. auris B8441 Ortholog(s) : B9J08_000417
C. glabrata CBS138 Ortholog(s) : CAGL0M11968g
View ortholog cluster : 19 genes among 19 Candida-related species/strains

Ortholog(s) in non-CGD species S. pombe (SPAC16E8.09) ; S. cerevisiae (CDC24)

Best hit(s) in non-CGD species A. nidulans (AN5592) ; N. crassa (cdc24)

JBrowse

JBrowse for feature C5_01970C_A

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GO Annotations View all CDC24 GO evidence and references

Molecular Function

Manually curated * guanyl-nucleotide exchange factor activity (ISS)

Biological Process

Manually curated * biological process involved in interspecies interaction between organisms (IMP)
* cell growth mode switching, budding to filamentous (IMP)
* cell morphogenesis (IMP)
* cellular response to biotic stimulus (IMP)
* establishment of cell polarity (IMP)
* filamentous growth (IMP)
* filamentous growth of a population of unicellular organisms in response to biotic stimulus (IMP)
* positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus (IMP)

Cellular Component

Manually curated * hyphal tip (IDA)

Mutant Phenotype View all CDC24 Phenotype details and references

Classical genetics

heterozygous null * viable

misexpression * hyphal growth: absent
* hyphal growth: decreased
* virulence: absent

overexpression * germ tube formation: abnormal
* invasive growth: normal
* viable

repressible * hyphal growth: abnormal
* inviable

Large-scale survey

heterozygous null * viable

null * inviable

repressible * virulence: decreased

Sequence Information

Ca22chr5A_C_albicans_SC5314:443334 to 440800 | JBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2014年06月24日 | Sequence: 2014年06月24日

Subfeature Details

		Relative Coordinates				Chromosomal Coordinates				Most Recent Update
		Relative Coordinates				Chromosomal Coordinates				Coordinates		Sequence
CDS		1	to	2535		443,334	to	440,800		2014年06月24日		2014年06月24日

Sequence Information Ca22chr5A_C_albicans_SC5314:443334 to 440800 | JBrowse
Note: this feature is encoded on the Crick strand.

Allele Location
Allele C5_01970C_B

Ca22chr5B_C_albicans_SC5314:443437 to 440903 | JBrowse
Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2016年01月21日 | Sequence: 2014年06月24日

Subfeature Details

		Relative Coordinates				Chromosomal Coordinates				Most Recent Update
		Relative Coordinates				Chromosomal Coordinates				Coordinates		Sequence
CDS		1	to	2535		443,437	to	440,903		2016年01月21日		2014年06月24日

Allele Location
Allele C5_01970C_B Ca22chr5B_C_albicans_SC5314:443437 to 440903 | JBrowse
Note: this feature is encoded on the Crick strand.

Primary CGDID CAL0000190069

ADDITIONAL INFORMATION for CDC24

Gene/Sequence Resources

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC24]

1) Mirbod F, et al. (1997) Molecular cloning of a Rho family, CDC42Ca gene from Candida albicans and its mRNA expression changes during morphogenesis. J Med Vet Mycol 35(3):173-9
CGD Papers Entry Pubmed Entry Reference LINKOUT

2) CandidaDB
CGD Papers Entry

3) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19.
CGD Papers Entry

4) CGD (2005) CGD comparison of orf6 and orf19 predicted protein products.
CGD Papers Entry

5) Maglott D, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 35(Database issue):D26-31
CGD Papers Entry Pubmed Entry Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT

6) Bassilana M, et al. (2003) Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans. Eukaryot Cell 2(1):9-18
CGD Papers Entry Pubmed Entry Reference LINKOUT

7) Cheng S, et al. (2003) Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Mol Microbiol 48(5):1275-88
CGD Papers Entry Pubmed Entry Reference LINKOUT

8) Bassilana M, et al. (2005) Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth. Eukaryot Cell 4(3):588-603
CGD Papers Entry Pubmed Entry Reference LINKOUT

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To cite CGD, please use the following reference: Skrzypek MS, Binkley J, Binkley G, Miyasato SR, Simison M, Sherlock G (2017). The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data. Nucleic Acids Res 45 (D1); D592-D596; see How to cite CGD.

C. albicans CDC24/C5_01970C SummaryLast curated 2025年05月29日See the Literature Guide for most recent publications.

JBrowse for feature C5_01970C_A

C. albicans CDC24/C5_01970C Summary

Last curated 2025年05月29日
See the Literature Guide for most recent publications.