C. albicans GPA2/C3_02240C Summary

Last curated 2025年07月14日
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Summary
Locus History Literature Gene Ontology Phenotype Homologs Protein
GPA2 BASIC INFORMATION [ View References ]
Standard Name GPA21
Systematic Name, Reference Strain C3_02240C_A (C. albicans SC5314)
Assembly 19/21 Identifier orf19.1621
Alias CAG992
orf19.9189, IPF25624.13 , IPF4239.23 , Contig4-2798_00094 , orf6.64515 , CA40123 , CaO19.91896 , CaO19.16216 , orf19.1621, C3_02240C_B, C3_02240C
Feature Type ORF, Verified
Description G-protein alpha subunit; regulates filamentous growth, copper resistance; involved in cAMP-mediated glucose signaling; reports differ on role in cAMP-PKA pathway, MAP kinase cascade; Gpr1 C terminus binds Gpa2; regulates HWP1 and ECE1 (1, 7, 8, 9, 10)
Literature
Allele Name C3_02240C_B
Allelic Variation Non-synonymous variation between alleles
Sequence variation between alleles within 100 bp upstream of feature start coordinates
Sequence variation between alleles within 100 bp downstream of feature end coordinates
CUG Codons C3_02240C_A: 2
C3_02240C_B: 2
Systematic Names Used in Other Strains CAWG_02550 (C. albicans WO-1)
Orthologous genes in Candida species C. auris B8441 Ortholog(s) : B9J08_002635/GPA2
C. dubliniensis CD36 Ortholog(s) : Cd36_82210
C. parapsilosis CDC317 Ortholog(s) : CPAR2_405100
C. glabrata CBS138 Ortholog(s) : CAGL0I08195g
View ortholog cluster : 19 genes among 19 Candida-related species/strains
Ortholog(s) in non-CGD species A. nidulans (ganB) ; N. crassa (gna-3) ; S. pombe (SPAC23H3.13c) ; S. cerevisiae (GPA2)
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JBrowse for feature C3_02240C_A

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GO Annotations View all GPA2 GO evidence and references

Molecular Function
Computational * G protein-coupled receptor binding (IEA with EBI: Fungal G-protein, alpha subunit)
* G-protein beta/gamma-subunit complex binding (IEA with EBI: Guanine nucleotide binding protein (G-protein), alpha subunit)
* GTP binding (IEA with S. pombe: SPAC23H3.13c)
* adenylate cyclase activator activity (IEA with S. pombe: SPAC23H3.13c)
* guanyl nucleotide binding (IEA with EBI: Guanine nucleotide binding protein (G-protein), alpha subunit)

Biological Process
Manually curated * G protein-coupled receptor signaling pathway (IGI with C. albicans: GPR1)
* adenylate cyclase-activating G protein-coupled receptor signaling pathway (IMP)
* biological process involved in interspecies interaction between organisms (IMP)
* cellular response to biotic stimulus (IMP)
* cellular response to glucose stimulus (IMP)
* cellular response to neutral pH (IMP)
* cellular response to starvation (IMP)
* filamentous growth (IMP)
* filamentous growth of a population of unicellular organisms (IMP)
* NOT: filamentous growth of a population of unicellular organisms in response to biotic stimulus (IMP)
* filamentous growth of a population of unicellular organisms in response to biotic stimulus (IMP)
* filamentous growth of a population of unicellular organisms in response to heat (IMP)
* filamentous growth of a population of unicellular organisms in response to neutral pH (IMP)
* filamentous growth of a population of unicellular organisms in response to starvation (IMP, IGI with C. albicans: GPR1)
* fungal-type cell wall (1->3)-beta-D-glucan metabolic process (IMP)
* intracellular copper ion homeostasis (IMP)
* invasive growth in response to heat (IMP)
* positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus (IMP)
* positive regulation of filamentous growth of a population of unicellular organisms in response to heat (IMP)
* positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH (IMP)
* positive regulation of filamentous growth of a population of unicellular organisms in response to starvation (IMP)
* response to pheromone triggering conjugation with cellular fusion (IMP)
* signal transduction involved in filamentous growth (IMP, IGI with C. albicans: GPR1)
Computational * G protein-coupled receptor signaling pathway (IEA with EBI: Guanine nucleotide binding protein (G-protein), alpha subunit, EBI: Fungal G-protein, alpha subunit)
* adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway (IEA with S. pombe: SPAC23H3.13c)
* negative regulation of induction of conjugation with cellular fusion (IEA with S. pombe: SPAC23H3.13c)
* negative regulation of transcription by RNA polymerase II (IEA with S. pombe: SPAC23H3.13c)

Cellular Component
Computational * heterotrimeric G-protein complex (IEA with S. pombe: SPAC23H3.13c)
Mutant Phenotype View all GPA2 Phenotype details and references
Classical genetics
activation * filamentous growth: increased
* hyphal growth: delayed
* viable
* virulence: decreased

dominant negative * hyphal growth: absent
* invasive growth: absent

heterozygous null * viable
* virulence: normal

homozygous null * 3',5'-cyclic AMP accumulation: decreased
* cold sensitivity: increased
* filamentous growth: decreased
* germ tube formation: absent
* hyphal growth: abnormal
* hyphal growth: decreased
* hyphal growth: normal
* invasive growth: decreased
* phenotypic switching: abnormal
* pheromone sensitivity: increased
* viable
* virulence: normal

Large-scale survey
homozygous null * colony appearance: abnormal
* competitive fitness: decreased
* vegetative growth: normal rate
* viable

null * viable

repressible * vegetative growth: normal rate
* viable

Sequence Information Ca22chr3A_C_albicans_SC5314:486369 to 484858 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年06月22日 | Sequence: 2016年06月22日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to1512486,369to484,8582016年06月22日2016年06月22日

Retrieve Sequences
Sequence Analysis Tools
Maps & Displays
Sequence Information Ca22chr3A_C_albicans_SC5314:486369 to 484858 | JBrowse
Note: this feature is encoded on the Crick strand.
Allele Location
Allele C3_02240C_B 		Ca22chr3B_C_albicans_SC5314:486408 to 484900 | JBrowse
Note: this feature is encoded on the Crick strand.
Last UpdateCoordinates: 2016年06月22日 | Sequence: 2016年06月22日

Subfeature Details
Relative
Coordinates		Chromosomal
Coordinates		Most Recent Update
CoordinatesSequence
CDS 1to1509486,408to484,9002016年06月22日2016年06月22日

Allele Location
Allele C3_02240C_B Ca22chr3B_C_albicans_SC5314:486408 to 484900 | JBrowse
Note: this feature is encoded on the Crick strand.
External Links BioGRID | CGOB | Entrez Gene (1, 2) | Fungal Orthologs | FungiDB | GenBank (1, 2, 3, 4, 5, 6) | Non-periodic Expression | Pedant | PhylomeDB | TrEMBL
Primary CGDID CAL0000186613
ADDITIONAL INFORMATION for GPA2
Gene/Sequence Resources
REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GPA2]
1) Sanchez-Martinez C and Perez-Martin J (2002) Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans. Eukaryot Cell 1(6):865-74
CGD Papers Entry Pubmed Entry Reference LINKOUT
2) Brown AJ and Gow NA (1999) Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol 7(8):333-8
CGD Papers Entry Pubmed Entry Reference LINKOUT
3) CandidaDB
CGD Papers Entry
4) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19.
CGD Papers Entry
5) CGD (2005) CGD comparison of orf6 and orf19 predicted protein products.
CGD Papers Entry
6) Maglott D, et al. (2007) Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 35(Database issue):D26-31
CGD Papers Entry Pubmed Entry Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT Reference LINKOUT
7) Miwa T, et al. (2004) Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. Eukaryot Cell 3(4):919-31
CGD Papers Entry Pubmed Entry Reference LINKOUT
8) Maidan MM, et al. (2005) The G protein-coupled receptor Gpr1 and the Galpha protein Gpa2 act through the cAMP-protein kinase A pathway to induce morphogenesis in Candida albicans. Mol Biol Cell 16(4):1971-86
CGD Papers Entry Pubmed Entry Reference LINKOUT
9) Wilson D, et al. (2010) Candida albicans Pde1p and Gpa2p comprise a regulatory module mediating agonist-induced cAMP signalling and environmental adaptation. Fungal Genet Biol 47(9):742-52
CGD Papers Entry Pubmed Entry Reference LINKOUT
10) Gutierrez-Escobedo G, et al. (2013) Role of glutathione in the oxidative stress response in the fungal pathogen Candida glabrata. Curr Genet 59(3):91-106
CGD Papers Entry Pubmed Entry Reference LINKOUT

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