Systematic Name, Reference Strain C3_01830C_A (C. albicans SC5314) |
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Alias KRE22 orf19.9232, IPF25631.1 3 , IPF6319.2 3 , Contig4-3069_0003 4 , orf6.5738 5 , CA3467 3 , CaO19.9232 6 , CaO19.1663 6 , orf19.1663, C3_01830C_B, C3_01830C |
Feature Type ORF, Verified |
Description Alpha-1,2-mannosyl transferase; adds 3rd mannose in cell-wall mannoprotein biosynthesis; partially redundant with Mnt1; role in adherence and virulence; expressed in yeast and hyphae; fungal-specific; Hap43-induced; Spider biofilm induced ( 7, 8, 9, 10) |
Allele Name C3_01830C_B |
Allelic Variation Non-synonymous variation between alleles |
CUG Codons C3_01830C_A: 3
C3_01830C_B: 3 |
Systematic Names Used in Other Strains CAWG_02514 (C. albicans WO-1) |
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Ortholog(s) in non-CGD species S. cerevisiae ( KRE2) |
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JBrowse
JBrowse for feature C3_01830C_A
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Molecular Function
Biological Process
Cellular Component |
Classical genetics Large-scale survey |
| Sequence Information | Ca22chr3A_C_albicans_SC5314:406585 to 405200 | JBrowse
Note: this feature is encoded on the Crick strand. | | Last Update | Coordinates: 2016年06月22日 | Sequence: 2016年06月22日 | | Subfeature Details | | | Relative
Coordinates | | Chromosomal
Coordinates | | Most Recent Update |
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| Coordinates | | Sequence | | CDS | | 1 | to | 1386 | | 406,585 | to | 405,200 | | 2016年06月22日 | | 2016年06月22日 |
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Sequence Information Ca22chr3A_C_albicans_SC5314:406585 to 405200 | JBrowse Note: this feature is encoded on the Crick strand. |
Allele Location
Allele C3_01830C_B | Ca22chr3B_C_albicans_SC5314:406636 to 405251 | JBrowse
Note: this feature is encoded on the Crick strand. | | Last Update | Coordinates: 2016年06月22日 | Sequence: 2016年06月22日 | | Subfeature Details | | | Relative
Coordinates | | Chromosomal
Coordinates | | Most Recent Update |
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| Coordinates | | Sequence | | CDS | | 1 | to | 1386 | | 406,636 | to | 405,251 | | 2016年06月22日 | | 2016年06月22日 |
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Allele Location
Allele C3_01830C_B Ca22chr3B_C_albicans_SC5314:406636 to 405251 | JBrowse Note: this feature is encoded on the Crick strand. |
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Primary CGDID CAL0000188888 |
ADDITIONAL INFORMATION for MNT2 |
LOCUS SUMMARY NOTES for MNT2 (Last Updated: 2011年05月18日) - Mnt2p is an alpha-1,2-mannosyl transferase that functions in O-glycosylation during cell-wall mannoprotein biosynthesis; in C. albicans, O-glycans are linear oligosaccharides of one to five alpha-1,2-linked mannose residues; Mnt2p adds the third mannose residue and is is partially redundant with Mnt1p (8)
- the mnt1 mnt2 mutant lacks the 4 terminal O-linked alpha-1,2-mannosyl residues which are important for stimulating TLR4-dependent cytokine responses during infection of human mononuclear cells (11)
- mnt2 mutants are reduced in adherence to human buccal epithelial cells and Matrigel-coated surfaces, indicating a role for O-glycosylated cell wall proteins or O-mannan in adhesion to host surfaces (8)
- the evaluation of adherence properties of mnt2 mutants is complicated by the URA3 status of the strain; ura3 strains used as controls show decreased adhesion (12)
- Mnt2p plays a role in role in virulence; mnt1 mnt2 double mutants are attenuated in virulence in a mouse model of systemic infection (8)
- the transcript is upregulated during the mating process of C. albicans (13)
- its expression is modestly induced during cell wall regeneration following protoplasting (14)
- MNT2 has also been called KRE2
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4) Berman J (2005) Mapping of ORFs in Assembly 4 to those in Assembly 19. CGD Papers Entry 5) CGD (2005) CGD comparison of orf6 and orf19 predicted protein products. CGD Papers Entry 7) Field D, et al. (1996) Use of polymorphic short and clustered coding-region microsatellites to distinguish strains of Candida albicans. FEMS Immunol Med Microbiol 15(2-3):73-9 CGD Papers Entry Pubmed Entry Reference LINKOUT 8) Munro CA, et al. (2005) Mnt1p and Mnt2p of Candida albicans are partially redundant alpha-1,2-mannosyltransferases that participate in O-linked mannosylation and are required for adhesion and virulence. J Biol Chem 280(2):1051-60 CGD Papers Entry Pubmed Entry Reference LINKOUT 9) Singh RP, et al. (2011) Cap2-HAP complex is a critical transcriptional regulator that has dual but contrasting roles in regulation of iron homeostasis in Candida albicans. J Biol Chem 286(28):25154-70 CGD Papers Entry Pubmed Entry Reference LINKOUT Data 11) Netea MG, et al. (2006) Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest 116(6):1642-50 CGD Papers Entry Pubmed Entry Reference LINKOUT |
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To cite CGD, please use the following
reference: Skrzypek MS, Binkley J, Binkley G, Miyasato SR, Simison M, Sherlock G (2017). The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data.
Nucleic Acids Res 45 (D1); D592-D596; see
How to cite CGD.