This page displays GO annotations in different sections according to the methods used in the reference from which the annotation was made:
- Manually Curated GO Annotations: includes annotations based on published experiments or analyses that focus on specific genes.
- GO Annotations from High-throughput Experiments: includes annotations made from published experiments performed on a high-throughput or genome-wide basis.
- Computational GO Annotations: includes annotations that are predicted by computational methods (e.g., sequence similarity comparisons) and are not individually reviewed.
| Manually Curated Molecular Function | |||
|---|---|---|---|
| Annotation(s) | Reference(s) | Evidence | Assigned By |
| protein kinase activity | Lee Y, et al. (2023) Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments. iScience 26(3):106145 CGD Papers Entry Pubmed Entry | IMP : Inferred from Mutant Phenotype Assigned on 2023年04月10日 | CGD |
| Manually Curated Biological Process | |||
|---|---|---|---|
| Annotation(s) | Reference(s) | Evidence | Assigned By |
| positive regulation of filamentous growth | Lee Y, et al. (2023) Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments. iScience 26(3):106145 CGD Papers Entry Pubmed Entry | IMP : Inferred from Mutant Phenotype Assigned on 2023年04月10日 | CGD |
*Manually Curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually Curated annotations are assigned by CGD curators based on published, small-scale experiments. Curators periodically review all Manually Curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.
** GO annotation from High-throughput Experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than CGD curators. While CGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation is not necessarily reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.
| Computational Predictions for Molecular Function | |||
|---|---|---|---|
| Annotation(s) | Reference(s) | Evidence | Assigned By |
| ATP binding | CGD (2011) Prediction of Gene Ontology (GO) annotations based on protein characteristics (e.g., domains and motifs) CGD Papers Entry | IEA : Inferred from Electronic Annotation with EBI: Protein kinase, ATP binding site, EBI: Protein kinase domain Assigned on 2024年01月09日 | CGD |
| RNA polymerase II CTD heptapeptide repeat S2 kinase activity | CGD (2008) Prediction of Gene Ontology (GO) annotations based on orthology CGD Papers Entry | IEA : Inferred from Electronic Annotation with S. pombe: SPAC2F3.15 Assigned on 2024年01月10日 | CGD |
| RNA polymerase II CTD heptapeptide repeat kinase activity | CGD (2008) Prediction of Gene Ontology (GO) annotations based on orthology CGD Papers Entry | IEA : Inferred from Electronic Annotation with S. pombe: SPAC2F3.15 Assigned on 2024年01月10日 | CGD |
| protein kinase activity | CGD (2011) Prediction of Gene Ontology (GO) annotations based on protein characteristics (e.g., domains and motifs) CGD Papers Entry | IEA : Inferred from Electronic Annotation with EBI: Protein kinase domain, EBI: Serine/threonine-protein kinase, active site Assigned on 2024年01月09日 | CGD |
| Computational Predictions for Biological Process | |||
|---|---|---|---|
| Annotation(s) | Reference(s) | Evidence | Assigned By |
| positive regulation of transcription by RNA polymerase II | CGD (2008) Prediction of Gene Ontology (GO) annotations based on orthology CGD Papers Entry | IEA : Inferred from Electronic Annotation with S. pombe: SPAC2F3.15 Assigned on 2024年01月10日 | CGD |
| protein phosphorylation | CGD (2011) Prediction of Gene Ontology (GO) annotations based on protein characteristics (e.g., domains and motifs) CGD Papers Entry | IEA : Inferred from Electronic Annotation with EBI: Protein kinase domain, EBI: Serine/threonine-protein kinase, active site Assigned on 2024年01月09日 | CGD |
| Computational Predictions for Cellular Component | |||
|---|---|---|---|
| Annotation(s) | Reference(s) | Evidence | Assigned By |
| chromatin | CGD (2008) Prediction of Gene Ontology (GO) annotations based on orthology CGD Papers Entry | IEA : Inferred from Electronic Annotation with S. pombe: SPAC2F3.15 Assigned on 2024年01月10日 | CGD |
| nuclear cyclin-dependent protein kinase holoenzyme complex | CGD (2008) Prediction of Gene Ontology (GO) annotations based on orthology CGD Papers Entry | IEA : Inferred from Electronic Annotation with S. pombe: SPAC2F3.15 Assigned on 2024年01月10日 | CGD |
*** Computational GO annotations are predictions based on computational methods (e.g., sequence similarity comparisons) and are not individually reviewed by a curator.