Antihypertensive therapy tailored to the circadian blood pressure profile as precision medicine
- Francesca Coccina
- Chiara Cuccurullo
- Sante D. Pierdomenico
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In heart failure with reduced ejection fraction (HFrEF) having hypertension, elevated serum adiponectin decreased following guideline-directed medical therapy (GDMT) and comprehensive cardiac rehabilitation (CCR). This reduction was associated with left ventricular ejection fraction (LVEF) improvement, suggesting adiponectin as a potential biomarker of therapeutic effects on cardiac metabolism in hypertensive HFrEF.
Along with age-related physiological decline, zinc deficiency and polypharmacy often exacerbate impaired taste perception, which poses a significant barrier to dietary salt restriction in the elderly. Zinc-containing polaprezinc can be an adjunctive strategy to safely improve taste sensitivity and facilitate dietary salt reduction in older patients with hypertension