Clinical Pharmacology: Advances and Applications

Dove Medical Press is pleased to invite you to submit your research to an upcoming Article Collection on "Metabolic Syndrome and Cardiovascular Disease", organized by Guest Advisors Dr. Constantine E. Kosmas and Dr. Christina Kostara in Clinical Pharmacology: Advances and Applications.

Metabolic syndrome (MetS) is characterized by a constellation of metabolic abnormalities, including obesity (especially central obesity), insulin resistance, hypertension, hypertriglyceridemia, and low levels of high-density lipoprotein cholesterol (HDL-C). Each of these metabolic abnormalities represents an independent risk factor for cardiovascular disease (CVD), and their combination significantly increases the risk of a spectrum of cardiovascular conditions, including microvascular dysfunction, coronary atherosclerosis and calcification, cardiac dysfunction, myocardial infarction, and heart failure.

MetS is strongly associated with cardiovascular morbidity and mortality. Patients with MetS have a higher risk of developing CVD compared with those without MetS in the next 5–10 years, and the long-term CVD risk is even higher. While advances in understanding the etiology and consequences of MetS have been made, the underlying pathophysiologic mechanisms that conspire into the full spectrum of the observed MetS-associated cardiovascular pathologies remain insufficiently explained.

This Article Collection aims to highlight current knowledge pertaining to the pathophysiological mechanisms underlying MetS-associated cardiovascular entities and the clinical phenotyping of metabolic syndrome, as well as the advanced research in drug development based on experimental or clinical research studies and the therapeutic interventions to reduce the cardiovascular burden of metabolic syndrome. We welcome submissions (original articles, reviews, or short communications) from clinical, translational, and basic research.

All manuscripts submitted to this Article Collection will undergo desk assessment and peer review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are existing members of the Editorial Board. Please review the journal's Aims and Scope and author submission instructions prior to submitting a manuscript.

Keywords

• Metabolic Syndrome
• Cardiovascular Disease
• Therapeutic interventions
• Atherosclerosis
• Cardiovascular Risk factors

All manuscripts submitted to this Article Collection will undergo desk assessment and peer-review as part of our standard editorial process. Guest Advisors for this collection will not be involved in peer-reviewing manuscripts unless they are an existing member of the Editorial Board. Please review the journal Aims and Scope and author submission instructions prior to submitting a manuscript.

The deadline for submitting manuscripts is 31 December 2025.

Please submit your manuscript on our website, quoting the promo code WPKNP for a 10% discount on the Article Processing Charge and to indicate that your submission is for consideration in this Article Collection.

Guest Advisors

Dr. Constantine E. Kosmas, 2nd Department of Cardiology, National & Kapodistrian University of Athens, Greece

[email protected]

Constantine E. Kosmas, M.D., Ph.D., FACC, FACP is a Clinical/Academic/Non-Invasive Cardiologist and Clinical Lipidologist, currently serving as a Scientific Associate of the Lipid Clinic at the 2nd Department of Cardiology of the National and Kapodistrian University of Athens at the University General Hospital “ATTIKON”.

He has served for a long time (2014-2023) as Director of Nuclear Cardiology and Lipid Clinic at a large private practice in New York (Cardiology Unlimited, P.C.). He has also served as Assistant Professor of Medicine at Icahn School of Medicine at Mount Sinai and Medical Director of Mount Sinai Advanced Cardiovascular Group, as well as Clinical Assistant Professor of Medicine at the Medical School of the University of Pennsylvania and at the Weill Medical College of Cornell University. Dr. Kosmas has also served as Director of Clinical Services and Associate Director of Nuclear Cardiology at Episcopal Hospital, Philadelphia, PA, as well as Acting Director of Coronary Care Unit at New York Hospital Queens, Flushing, New York.

Dr. Kosmas holds Board Certifications in Internal Medicine and Cardiovascular Disease in the USA and Greece, as well as Board Certifications in Nuclear Cardiology and Clinical Lipidology in the United States. He has been extensively involved in teaching mid-level providers, students, medical residents, and cardiology fellows at several academic institutions in New York and Pennsylvania. He has also been extensively involved in cardiovascular clinical research with several publications in the medical literature and numerous lectures in academic institutions and national conferences, especially on lipid-related subjects. Dr. Kosmas has also served as a member of the American Board of Internal Medicine (ABIM)’s Cardiovascular Disease Item-Writing Task Force. In addition, he has served as a member of many Speaker Bureaus and Advisory Boards of several large international pharmaceutical companies. Dr. Kosmas is an active member of the Editorial Board as well as a Reviewer in several prestigious peer-reviewed medical journals.

Dr. Christina Kostara, Laboratory of Clinical Chemistry, Faculty of Medicine, School of Health Sciences, University of Ioannina, Greece

[email protected]

Christina Kostara is a Post-Doctoral Researcher in the Faculty of Medicine at the University of Ioannina, Greece.

Dr. Kostara’s main research interest focuses on the investigation of lipid profiling (Lipidomics) as a novel approach for the analysis of biological matrixes using high resolution nuclear magnetic resonance spectroscopy (NMR) combined with high throughput “omics” technologies.

View all papers in this article collection

Editor-in-Chief: Professor Arthur E Frankel