Hiroji Aiba

Profile Information

Affiliation

Professor, Graduate School of Science, Division of Biological Science, Graduate School of Science,School of Science Biological Science, Nagoya University

Degree

薬学修士

薬学博士

J-GLOBAL ID

200901038459196825

researchmap Member ID

1000024796

Research Interests

• リボソーム
• tmRNA
• 品質管理
• トランス翻訳
• mRNA分解
• 翻訳制御
• ノンコーディングRNA
• ストレス応答
• グルコース代謝
• 解糖系
• 大腸菌
• 遺伝子発現調節
• ribosome
• tmRNA
• quality control
• trans-translation
• mRNA degradation
• translational regulation
• noncoding RNA
• stress response
• glucose metabolism
• glycolysis
• Escherichia coli
• regulation of gene expression

Research Areas

• Life sciences / Molecular biology /

Committee Memberships

• 2006

  評議員, 日本RNA学会
• 1989 - 1992

  評議員, 日本分子生物学会
• 1992

  評議員, 日本生化学会

Misc.

• RNA, but not protein partners, is directly responsible for translational silencing by a bacterial Hfq-binding small RNA

  Kimika Maki, Kanako Uno, Teppei Morita, Hiroji Aiba

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(30) 10332-10337, Jul, 2008
• Cleavage of mRNAs and role of tmRNA system under amino acid starvation in Escherichia coli

  Xia Li, Mieko Yagi, Teppei Morita, Hiroji Aiba

  MOLECULAR MICROBIOLOGY, 68(2) 462-473, Apr, 2008
• ANALYSES OF MRNA DESTABILIZATION AND TRANSLATIONAL INHIBITION MEDIATED BY HFQ-BINDING SMALL RNAS

  Teppei Morita, Kimika Maki, Mieko Yagi, Hiroji Aiba

  RNA TURNOVER IN BACTERIA, ARCHAEA AND ORGANELLES, 447 359-378, 2008
• Small RNAs making a small protein

  Teppei Morita, Hiroji Aiba

  Proceedings of the National Academy of Sciences of the United States of America, 104(51) 20149-20150, Dec 18, 2007
• Small RNAs making a small protein

  Teppei Morita, Hiroji Aiba

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(51) 20149-20150, Dec, 2007
• Mechanism of RNA silencing by Hfq-binding small RNAs

  Hiroji Aiba

  CURRENT OPINION IN MICROBIOLOGY, 10(2) 134-139, Apr, 2007
• Mechanism of RNA silencing by Hfq-binding small RNAs

  Hiroji Aiba

  Current Opinion in Microbiology, 10(2) 134-139, Apr, 2007
• 大腸菌低分子RNAによる遺伝子発現抑制機構

  化学と生物, 45(5) 298-300, 2007
• Reduced action of polypeptide release factors induces mRNA cleavage and tmRNA tagging at stop codons in Escherichia coli

  Xia Li, Teruaki Yokota, Koichi Ito, Yoshikazu Nakamura, Hiroji Aiba

  MOLECULAR MICROBIOLOGY, 63(1) 116-126, Jan, 2007
• YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12

  Ann-Katrin Becker, Tim Zeppenfeld, Ariane Staab, Sabine Seitz, Winfried Boos, Teppei Morita, Hiroji Aiba, Kerstin Mahr, Fritz Titgemeyer, Knut Jahreis

  JOURNAL OF BACTERIOLOGY, 188(15) 5439-5449, Aug, 2006
• Base-pairing requirement for RNA silencing by a bacterial small RNA and acceleration of duplex formation by Hfq

  Hiroshi Kawamoto, Yukari Koide, Teppei Morita, Hiroji Aiba

  MOLECULAR MICROBIOLOGY, 61(4) 1013-1022, Aug, 2006
• Translational repression is sufficient for gene silencing by bacterial small noncoding RNAs in the absence of mRNA destruction

  T Morita, Y Mochizuki, H Aiba

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(13) 4858-4863, Mar, 2006
• Protein tagging at rare codons is caused by tmRNA action at the 3 ' end of nonstop mRNA generated in response to ribosorne stalling

  Li, X, R Hirano, H Tagami, H Aiba

  RNA-A PUBLICATION OF THE RNA SOCIETY, 12(2) 248-255, Feb, 2006
• Protein tagging at rare codons is caused by tmRNA action at the 3 ' end of nonstop mRNA generated in response to ribosorne stalling

  Li, X, R Hirano, H Tagami, H Aiba

  RNA-A PUBLICATION OF THE RNA SOCIETY, 12(2) 248-255, Feb, 2006
• 大腸菌small RNAによるRNA サイレンシングの分子機構

  森田 鉄兵, 饗場 弘二

  蛋白質 核酸 酵素, 51(16) 2478-2483, 2006
• RNase E-based ribonucleoprotein complexes: mechanical basis of mRNA destabilization mediated by bacterial noncoding RNAs

  T Morita, K Maki, H Aiba

  GENES & DEVELOPMENT, 19(18) 2176-2186, Sep, 2005
• Translation of aberrant mRNAs lacking a termination codon or with a shortened 3′-UTR is repressed after initiation in yeast

  Toshifumi Inada, Hiroji Aiba

  EMBO Journal, 24(8) 1584-1595, Apr 20, 2005
• Implication of membrane localization of target mRNA in the action of a small RNA: mechanism of post-transcriptional regulation of glucose transporter in Escherichia coli

  H Kawamoto, T Morita, A Shimizu, T Inada, H Aiba

  GENES & DEVELOPMENT, 19(3) 328-338, Feb, 2005
• New Aspects of Regulatory Network in Glucose Metabolism

  MORITA Teppei, AIBA Hiroji

  KAGAKU TO SEIBUTSU, 43(4) 222-228, 2005
• Enolase in the RNA degradosome plays a crucial role in the rapid decay of glucose transporter mRNA in the response to phosphosugar stress in Escherichia coli

  T Morita, H Kawamoto, T Mizota, T Inada, H Aiba

  MOLECULAR MICROBIOLOGY, 54(4) 1063-1075, Nov, 2004

Books and Other Publications

• Bioscience 新用語ライブラリー 転写因子

  羊土社, 1999
• DNAse I フットプリンティング法. 新遺伝子工学ハンドブック

  羊土社, 1999
• Encyclopedia of Molecular Biology (Thomas E. Creighton eds)

  John Wiley & Sons, Inc, 1999
• Encyclopedia of Molecular Biology (Thomas E. Creighton eds)

  John Wiley & Sons, Inc, 1999
• 生化学辞典第3版

  東京化学同人, 1998
• 分子生物学辞典

  東京化学同人, 1997
• 新遺伝子工学ハンドブック DNaseIフットプリンティング法

  1996
• 岩波生物学辞典第4版

  岩波書店, 1995
• Bio Science 用語ライブラリー 転写因子(羊土社)大腸菌の転写因子概論、シグマ因子、CRP、NtrC、lacリプレッサー、

  羊土社, 1995
• 新生化学実験講座2核酸IV 原核生物のプロモーターと発現調節

  東京化学同人, 1993
• Mechanism of transcription activation by cAMP receptor protein in Escherichia coli. In Molecular Structure and life

  Japan Sci. Soc. Press. Tokyo/CRC Press, Boca Raton., 1992
• Mechanism of transcription activation by cAMP receptor protein in Escherichia coli. In Molecular Structure and life

  Japan Sci. Soc. Press. Tokyo/CRC Press, Boca Raton., 1992
• 日本分子生物学会編、分子生物学の進歩 第4巻「遺伝子の発現と制御」cAMPーCRP系の転写制御

  丸善, 1989
• 実験操作ブロッティング法 バクテリアRNAの調製

  ソフトサイエンス社, 1987
• 続生化学実験講座1 遺伝子研究法I 遺伝子ータンパク質相互作用の解析

  東京化学同人, 1986

Professional Memberships

• 日本分子生物学会
• 日本生化学会
• 日本RNA学会

Research Projects

• 大腸菌低分子RNAによる遺伝子発現調節機構

  2001
• Mechanism of gene regulation by small RNAs in Escherichia coli

  2001
• tmRNAとリボソームによる品質管理機構と遺伝子発現調節

  1996
• Quality control and gene regulation mediated by tmRNA and ribosome

  1996
• 大腸菌における解糖系制御ネットワーク

  1991
• Regulatory network of glycolysis in Escherichia coli

  1991