madoka tonosaki

Profile Information

Degree

Doctor of Philosophy(Mar, 2014, Kyoto Prefectural University of Medicine)

ORCID iD

https://orcid.org/0000-0002-6978-8356

J-GLOBAL ID

202401020721347075

researchmap Member ID

R000069052

Research Interests

• in utero electroporation, time lapse imaging

Research Areas

• Life sciences / Fetal medicine/Pediatrics / 子宮内電気穿孔法, タイムラプスイメージング, 発生神経生物学

Research History

• May, 2026 - Present

  Technician, School of Medicine, Keio University
• Apr, 2024 - Mar, 2026

  Reseach Assistant, Kyoto Prefectural University of Medicine
• Oct, 2023 - Mar, 2024

  Reseach Assistant, Kyoto Prefectural University of Medicine
• Apr, 2014 - Mar, 2023

  Project researcher, Kyoto Prefectural University of Medicine
• Apr, 2011 - Mar, 2014

  Reseach Assistant, Kyoto Prefectural University of Medicine

Education

• Mar, 2007 - Apr, 2011

  Graduate School of Medical Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

Papers

• Characterization of Dystrophin Dp71 Expression and Interaction Partners in Embryonic Brain Development: Implications for Duchenne/Becker Muscular Dystrophy.

  Takahiro Fujimoto, Miyuki Mori, Madoka Tonosaki, Takeshi Yaoi, Kenta Nakano, Tadashi Okamura, Kyoko Itoh

  Molecular neurobiology, Jan 6, 2025
• Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis

  Madoka Tonosaki, Akira Fujimori, Takeshi Yaoi, Kyoko Itoh

  PLOS ONE, 18(11) e0294893, Nov 29, 2023 Peer-reviewedLead author
• Loss of abnormal spindle-like, microcephaly-associated (Aspm) disrupts female folliculogenesis in mice during maturation and aging

  Miyuki Mori, So Tando, Hiroshi Ogi, Madoka Tonosaki, Takeshi Yaoi, Akira Fujimori, Kyoko Itoh

  Reproductive Biology, 22(3) 100673-100673, Sep, 2022 Peer-reviewed
• L1cam Is Crucial for Cell Locomotion and Terminal Translocation of the Soma in Radial Migration during Murine Corticogenesis

  Madoka Tonosaki, Kyoko Itoh, Masafumi Umekage, Tomokazu Kishimoto, Takeshi Yaoi, Vance P. Lemmon, Shinji Fushiki

  PLoS ONE, 9(1) e86186, Jan 28, 2014 Lead author
• Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex

  Tomokazu Kishimoto, Kyoko Itoh, Masafumi Umekage, Madoka Tonosaki, Takeshi Yaoi, Kenji Fukui, Vance P. Lemmon, Shinji Fushiki

  Journal of Neuroscience Research, 91(1) 42-50, Oct 17, 2012 Peer-reviewed

Major Presentations

• ヒト先天性小頭症(MCPH5)モデルマウス(Aspmコンディショナルノックアウト)の解析

  外﨑円, 藤森亮, 藤本崇宏, 矢追毅, 伊東恭子

  第63回日本神経病理学会総会, Jun 25, 2022
• Presumptive function of microcephaly related gene Aspm during murine brain development

  Tonosaki M, Fujimori A, Yaoi T, Itoh K

  ICN2018, Sep 24, 2018
• 細胞接着分子L1camはマウス大脳皮質形成過程における神経細胞放射状遊走に不可欠である

  外﨑円, 伊東恭子, 伏木信次

  第55回日本神経病理学会総会, Jun 7, 2014
• 神経細胞接着分子L1camは大脳皮質形成過程における放射状神経細胞移動に必須である

  外崎円, 伊東恭子, 伏木信次

  第56回日本小児神経学会学術集会, May 29, 2014

Research Projects

• Does hereditary microcephalic responsible gene ASPM control a cell cycle and cell death in the neurogenesis process?

  Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

  Tonosaki Madoka
• Analysis of lifelong molecular function of ASPM, responsible gene for human hereditary microcephaly, in the brain

  Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

  Tonosaki Madoka, FUJIMORI AKIRA