Reactome Pathway Database

Schema > Reaction > Entries

(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H Show undefined attributes

catalystActivity

[CatalystActivity:10608493] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of HADH dimer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10603480] Weiser, Joel, 2025年08月27日

dbId 10608537

displayName (S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H

eventOf

[Pathway:R-XTR-77352] Beta oxidation of butanoyl-CoA to acetyl-CoA - Xenopus tropicalis

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-XTR-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Xenopus tropicalis

inferredFrom

[Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H

output

precedingEvent

[Reaction:R-XTR-77314] Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA - Xenopus tropicalis

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:205621] Xenopus tropicalis

stId R-XTR-77312

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-XTR-77352] Beta oxidation of butanoyl-CoA to acetyl-CoA

(precedingEvent)

[Reaction:R-XTR-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2

(inferredTo)

[Reaction:R-HSA-77312] (S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H

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