Reactome Pathway Database

Schema > Reaction > Entries

SLC25A11 exchanges 2-OG and MAL Show undefined attributes

catalystActivity

[CatalystActivity:10615802] oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]

category transition

compartment

created [InstanceEdit:10603480] Weiser, Joel, 2025年08月27日

dbId 10620095

displayName SLC25A11 exchanges 2-OG and MAL

eventOf

[Pathway:R-XTR-9856872] Malate-aspartate shuttle - Xenopus tropicalis

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

SLC25A11 exchanges 2-OG and MAL
SLC25A11 exchanges alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane
(S)-malate(out) + 2-oxoglutarate(in) => (S)-malate(in) + 2-oxoglutarate(out)

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:205621] Xenopus tropicalis

stId R-XTR-376851

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-XTR-9856872] Malate-aspartate shuttle

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL

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