Reactome Pathway Database

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CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 Show undefined attributes

catalystActivity

[CatalystActivity:10643764] protein-disulfide reductase activity of CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10603480] Weiser, Joel, 2025年08月27日

dbId 10643766

displayName CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1

eventOf

[Pathway:R-XTR-3299685] Detoxification of Reactive Oxygen Species - Xenopus tropicalis

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-XTR-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Xenopus tropicalis

inferredFrom

[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 - Homo sapiens

input

2 × [Complex:R-XTR-3299706] CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1

output

precedingEvent

[Reaction:R-XTR-8951723] 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates - Xenopus tropicalis

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:205621] Xenopus tropicalis

stId R-XTR-3299753

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-XTR-3299685] Detoxification of Reactive Oxygen Species

(precedingEvent)

[Reaction:R-XTR-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)

(inferredTo)

[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1

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