Reactome Pathway Database

Schema > Reaction > Entries

CYP7B1 7-hydroxylates 25OH-CHOL Show undefined attributes

catalystActivity

[CatalystActivity:10441669] oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10441748

displayName CYP7B1 7-hydroxylates 25OH-CHOL

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP7B1 7-hydroxylates 25OH-CHOL
25-hydroxycholesterol + O2 + reduced (NADPH--hemoprotein reductase) => 7alpha,25-dihydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

output

precedingEvent

[Reaction:R-SSC-5340195] NR1H4 binds DCA, CDCA, LCHA - Sus scrofa

regulatedBy

[NegativeRegulation:10441692] Negative regulation by 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-192065

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(inferredTo)

[Reaction:R-HSA-192065] CYP7B1 7-hydroxylates 25OH-CHOL

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