Reactome Pathway Database

Schema > Reaction > Entries

Autocatalytic activation of bound proMMP2 Show undefined attributes

catalystActivity

[CatalystActivity:10473516] serine-type endopeptidase activity of MMP14:TIMP2:MMP2 intermediate form [plasma membrane]

category transition

compartment

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10473518

displayName Autocatalytic activation of bound proMMP2

eventOf

[Pathway:R-SSC-1592389] Activation of Matrix Metalloproteinases - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-1604368] Autocatalytic activation of bound proMMP2 - Homo sapiens

input

[Complex:R-SSC-1604373] MMP14:TIMP2:MMP2 intermediate form [plasma membrane]

isInDisease false

isInferred true

maxDepth 1

name

Autocatalytic activation of bound proMMP2

output

precedingEvent

[Reaction:R-SSC-1604360] Initial activation of proMMP2 by MMP14 - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-1604368

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-1592389] Activation of Matrix Metalloproteinases

(inferredTo)

[Reaction:R-HSA-1604368] Autocatalytic activation of bound proMMP2

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