Reactome Pathway Database

Schema > Reaction > Entries

PP2A dephosphorylates inactive RAFs Show undefined attributes

catalystActivity

[CatalystActivity:10159743] protein serine/threonine phosphatase activity of PP2A [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10159759

displayName PP2A dephosphorylates inactive RAFs

eventOf

[Pathway:R-RNO-5673000] RAF activation - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-RNO-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Rattus norvegicus

inferredFrom

[Reaction:R-HSA-5672961] PP2A dephosphorylates inactive RAFs - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PP2A dephosphorylates inactive RAFs

output

precedingEvent

[Reaction:R-RNO-5672951] Inactive RAFs bind YWHAB - Rattus norvegicus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-5672961

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-5673000] RAF activation

(precedingEvent)

[Reaction:R-RNO-5672960] YWHAB dimer dissociates from dephosphorylated RAF

(inferredTo)

[Reaction:R-HSA-5672961] PP2A dephosphorylates inactive RAFs

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