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Entries
PP2A dephosphorylates inactive RAFs
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authored
[InstanceEdit:5658468] Rothfels, Karen, 2014年12月18日
catalystActivity
[CatalystActivity:5672955] protein serine/threonine phosphatase activity of PP2A [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5672959] Rothfels, Karen, 2015年02月06日
dbId
5672961
displayName
PP2A dephosphorylates inactive RAFs
edited
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
eventOf
[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
followingEvent
[Reaction:R-HSA-5672960] YWHAB dimer dissociates from dephosphorylated RAF - Homo sapiens
input
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[Complex:R-HSA-5672707] inactive RAFs:YWHAB dimer [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5672521] Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase
[LiteratureReference:208298] Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
[LiteratureReference:208163] Dephosphorylation of Ser-259 regulates Raf-1 membrane association
[LiteratureReference:208364] Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
[LiteratureReference:5672416] Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1
[LiteratureReference:5672517] RAF protein-serine/threonine kinases: structure and regulation
[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
[LiteratureReference:5672478] Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation
[LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization
[LiteratureReference:5672425] Active Ras induces heterodimerization of cRaf and BRaf
[LiteratureReference:5672454] Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling
[LiteratureReference:5674056] Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration
[LiteratureReference:5674053] Ras-Raf signaling needs prohibitin
[LiteratureReference:5674049] Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
PP2A dephosphorylates inactive RAFs
orthologousEvent
[Reaction:R-CEL-5672961] PP2A dephosphorylates inactive RAFs - Caenorhabditis elegans
[Reaction:R-DME-5672961] PP2A dephosphorylates inactive RAFs - Drosophila melanogaster
[Reaction:R-SSC-5672961] PP2A dephosphorylates inactive RAFs - Sus scrofa
[Reaction:R-BTA-5672961] PP2A dephosphorylates inactive RAFs - Bos taurus
[Reaction:R-RNO-5672961] PP2A dephosphorylates inactive RAFs - Rattus norvegicus
[Reaction:R-MMU-5672961] PP2A dephosphorylates inactive RAFs - Mus musculus
output
[Complex:R-HSA-5672728] dephosphorylated inactive RAFS:YWHAB dimer [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-5672951] Inactive RAFs bind YWHAB - Homo sapiens
releaseDate
2015年06月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5690572] Roskoski, Robert Jr, 2015年04月28日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5672961
summation
[Summation:5672627] Upon growth factor stimulation, RAF1 S259 (or S365 and S214 ...
Referrals
(hasEvent)
[Pathway:R-HSA-5673000] RAF activation
(precedingEvent)
[Reaction:R-HSA-5672960] YWHAB dimer dissociates from dephosphorylated RAF
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