Reactome Pathway Database

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Negative regulation of FGFR1 signaling Show undefined attributes

compartment

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10198883

displayName Negative regulation of FGFR1 signaling

eventOf

[Pathway:R-RNO-5654736] Signaling by FGFR1 - Rattus norvegicus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-RNO-5654560] Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 - Rattus norvegicus
[Reaction:R-RNO-5654673] p-CBL:GRB2 binds p-FRS2:activated FGFR1 - Rattus norvegicus
[Reaction:R-RNO-5654672] CBL ubiquitinates FRS2 and FGFR1 - Rattus norvegicus
[Pathway:R-RNO-1295596] Spry regulation of FGF signaling - Rattus norvegicus

inferredFrom

[Pathway:R-HSA-5654726] Negative regulation of FGFR1 signaling - Homo sapiens

isInDisease false

isInferred true

maxDepth 3

name

Negative regulation of FGFR1 signaling

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:48895] Rattus norvegicus

stId R-RNO-5654726

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-RNO-5654736] Signaling by FGFR1

(inferredTo)

[Pathway:R-HSA-5654726] Negative regulation of FGFR1 signaling

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