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Entries
Negative regulation of FGFR1 signaling
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authored
[InstanceEdit:1489508] Rothfels, K, 2011年08月15日
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654725] Rothfels, Karen, 2014年12月03日
crossReference
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
5654726
deleted
[Deleted:5655582] Deletion of instance: 1270470
displayName
Negative regulation of FGFR1 signaling
eventOf
[Pathway:R-HSA-5654736] Signaling by FGFR1 - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5654514] KAL1 binds FGFR1c - Homo sapiens
[Reaction:R-HSA-5654560] Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 - Homo sapiens
[Reaction:R-HSA-5654673] p-CBL:GRB2 binds p-FRS2:activated FGFR1 - Homo sapiens
[Reaction:R-HSA-5654672] CBL ubiquitinates FRS2 and FGFR1 - Homo sapiens
[Pathway:R-HSA-1295596] Spry regulation of FGF signaling - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
[LiteratureReference:1296088] Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
[LiteratureReference:1268080] FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
[LiteratureReference:1268103] Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function
maxDepth
3
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Negative regulation of FGFR1 signaling
orthologousEvent
[Pathway:R-MMU-5654726] Negative regulation of FGFR1 signaling - Mus musculus
[Pathway:R-CEL-5654726] Negative regulation of FGFR1 signaling - Caenorhabditis elegans
[Pathway:R-DME-5654726] Negative regulation of FGFR1 signaling - Drosophila melanogaster
[Pathway:R-GGA-5654726] Negative regulation of FGFR1 signaling - Gallus gallus
[Pathway:R-XTR-5654726] Negative regulation of FGFR1 signaling - Xenopus tropicalis
[Pathway:R-DRE-5654726] Negative regulation of FGFR1 signaling - Danio rerio
[Pathway:R-SSC-5654726] Negative regulation of FGFR1 signaling - Sus scrofa
[Pathway:R-BTA-5654726] Negative regulation of FGFR1 signaling - Bos taurus
[Pathway:R-CFA-5654726] Negative regulation of FGFR1 signaling - Canis familiaris
[Pathway:R-RNO-5654726] Negative regulation of FGFR1 signaling - Rattus norvegicus
releaseDate
2011年09月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
[InstanceEdit:8851378] Grose, Richard P, 2016年01月06日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5654726
summation
[Summation:1503116] Once activated, the FGFR signaling pathway is regulated by n...
updateTrackers
[UpdateTracker:9783599] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v56:[addHasEvent]
[UpdateTracker:9776172] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v77:[updateIndirectRLE]
[UpdateTracker:9864346] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v88:[updateIndirectRLE]
[UpdateTracker:9775606] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v78:[updateIndirectRLE]
Referrals
(updatedInstance)
[UpdateTracker:9783599] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v56:[addHasEvent]
[UpdateTracker:9776172] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v77:[updateIndirectRLE]
[UpdateTracker:9864346] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v88:[updateIndirectRLE]
[UpdateTracker:9775606] Update Tracker - [Pathway:5654726] Negative regulation of FGFR1 signaling - v78:[updateIndirectRLE]
(replacementInstances)
[Deleted:5655582] Deletion of instance: 1270470
(hasEvent)
[Pathway:R-HSA-5654736] Signaling by FGFR1
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