Reactome Pathway Database

Schema > Reaction > Entries

CYP11B1 oxidises 11DCORT Show undefined attributes

catalystActivity

[CatalystActivity:10102567] steroid 11-beta-monooxygenase activity of Cytochrome P450 (CYP11B1 based) [mitochondrial inner membrane]

category transition

compartment

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10102569

displayName CYP11B1 oxidises 11DCORT

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-193997] CYP11B1 oxidises 11DCORT - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

CYP11B1 oxidises 11DCORT
11-deoxycortisol + 2 H(+) + O2 + 2 reduced (adrenodoxin) => cortisol + H2O + 2 oxidized (adrenodoxin)
11-deoxycortisol is oxidised to cortisol by CYP11B1
11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O

output

regulatedBy

[PositiveRegulation:10102236] Positive regulation by 'POMC(138-176) [cytosol]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-193997

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(inferredTo)

[Reaction:R-HSA-193997] CYP11B1 oxidises 11DCORT

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