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CYP11B1 oxidises 11DCORT Show undefined attributes

authored

[InstanceEdit:378946] Jassal, Bijay, 2008年10月01日

catalystActivity

[CatalystActivity:193999] steroid 11-beta-monooxygenase activity of Cytochrome P450 (CYP11B1 based) [mitochondrial inner membrane]

category transition

compartment

created [InstanceEdit:194008] Jassal, B, 2007年03月06日 13:54:16

crossReference

[DatabaseIdentifier:9907735] RHEA:46101

dbId 193997

displayName CYP11B1 oxidises 11DCORT

edited

[InstanceEdit:196368] Jassal, B, 2007年04月20日 21:09:56

eventOf

[Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-194036] Cortisol translocates from the mitochondrial matrix to the cytosol - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10603480] Weiser, Joel, 2025年08月27日

name

CYP11B1 oxidises 11DCORT
11-deoxycortisol + 2 H(+) + O2 + 2 reduced (adrenodoxin) => cortisol + H2O + 2 oxidized (adrenodoxin)
11-deoxycortisol is oxidised to cortisol by CYP11B1
11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O

orthologousEvent

output

precedingEvent

[BlackBoxEvent:R-HSA-194025] 11-deoxycortisol translocates to the mitochondrion - Homo sapiens

previousReviewStatus [ReviewStatus:9821385] four stars

regulatedBy

[PositiveRegulation:R-HSA-1449717] Positive regulation by 'POMC(138-176) [cytosol]'

regulationReference

[RegulationReference:9642949] Positive regulation by 'POMC(138-176) [cytosol]' Clinical review 104: Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: neural and immune inputs

releaseDate 2007年05月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

revised

[InstanceEdit:5602271] Jassal, Bijay, 2014年06月23日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-193997

summation

[Summation:193986] Cytochrome P450 11B1, mitochondrial (CYP11B1) usually hydrox...

updateTrackers

Referrals

(updatedInstance)

(normalReaction)

[FailedReaction:R-HSA-5580292] Defective CYP11B1 does not oxidise 11DCORT

(hasEvent)

(precedingEvent)

[BlackBoxEvent:R-HSA-194036] Cortisol translocates from the mitochondrial matrix to the cytosol

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